Locomotory phenotypes of human tumor cell lines and T lymphocytes in a three-dimensional collagen lattice.
Locomotory phenotypes of human tumor cell lines and T lymphocytes in a three-dimensional collagen lattice.
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三维胶原晶格中人类肿瘤细胞系和 T 淋巴细胞的运动表型。
DOI：
10.1016/s0304-3835(97)00328-5
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发表时间：
1997
期刊：
影响因子：
9.7
通讯作者：
Peter Friedl
中科院分区：
文献类型：
--
作者：
B. Niggemann;Kerstin Maaser;Hongqi Lü;R. Kroczek;K. Zänker;Peter Friedl
Active cellular locomotion is a feature of such diverse cell types as lymphocytes and cancer cells. The locomotory phenotype of a cell should ultimately reflect the biochemical basis of different migratory strategies. We investigated the locomotory behavior of five epithelial cell lines and one non-epithelial human cell-line as well as human CD4+T lymphocytes in a three-dimensional collagen type I matrix using time-lapse video microscopy and computer assisted cell-tracking. Migration velocity was up to 70 times lower in tumor cells (0.1–0.3 μm/min) as compared to T lymphocytes (7–7.5 μm/min), whereas the percentage of spontaneously active cells was up to twice as high in tumor cells (80–90%) in comparison to T lymphocytes (54%). Persistence, i.e. the degree of roaming, varied appreciably between the different cell types. In conclusion, velocity and persistence may describe distinct migration strategies in different cell types, i.e. discerning T cell migration from tumor cell invasion.
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免疫缺陷小鼠中BT-474人类乳腺癌细胞的生长：一种新的体内体内模型，用于激素依赖性乳腺癌。
影响因子：
8.8
作者：
Van Slooten, H.-J.;Bonsing, B. A.;Hiller, A. J.;Colbern, G. T.;Van Dierendonck, J. H.;Cornelisse, C. J.;Smith, H. S.
通讯作者：
Smith, H. S.
影响因子：
11.2
作者：
J. Rheinwald;M. Beckett
通讯作者：
J. Rheinwald;M. Beckett
影响因子：
8.8
作者：
Meltzer P;Leibovitz A;Dalton W;Villar H;Kute T;Davis J;Nagle R;Trent J
通讯作者：
Trent J
培养的人原发性、复发性皮肤和转移性黑色素瘤中的细胞迁移和肌动蛋白组织。
DOI：
--
发表时间：
1991
期刊：
The American journal of pathology
影响因子：
--
作者：
Byers,HR;Etoh,T;Doherty,JR;Sober,AJ;MihmJr,MC
通讯作者：
MihmJr,MC
DOI：
10.1073/pnas.86.4.1254
发表时间：
1989-02-01
影响因子：
11.1
作者：
PARTIN, AW;SCHOENIGER, JS;COFFEY, DS
通讯作者：
COFFEY, DS