Near-infrared phosphorescent polymeric nanomicelles: efficient optical probes for tumor imaging and detection.
Near-infrared phosphorescent polymeric nanomicelles: efficient optical probes for tumor imaging and detection.
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DOI：
10.1021/am9001293
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发表时间：
2009-07
影响因子：
9.5
通讯作者：
Prasad, Paras N.
中科院分区：
文献类型：
--
作者：
Kumar, Rajiv;Ohulchanskyy, Tymish Y.;Roy, Indrajit;Gupta, Sandesh K.;Borek, Carsten;Thompson, Mark E.;Prasad, Paras N.
关键词：
We report a formulation of near infrared (NIR) phosphorescent polymeric nanomicelles and their use for in vivo high contrast optical imaging, targeting and detection of tumors in small animals. NIR phosphorescent molecules of Pt(II)-tetraphenyltetranaphthoporphyrin [Pt(TPNP)] were found to maintain their NIR phosphorescence properties when encapsulated into phospholipid nanomicelles. The prepared phosphorescent micelles are of ~100 nm size and are highly stable in aqueous suspensions. A large spectral separation between Pt(TPNP) absorption, peaked at ~700 nm, and its phosphorescence emission, with peak at ~ 900 nm, allows a dramatic decrease in the level of background autofluorescence and scattered excitation light in the NIR spectral range, where the signal from phosphorescent probe is observed. In vivo animal imaging with subcutaneously xenograted tumor-bearing mice has resulted in high contrast optical images, indicating highly specific accumulation of the phosphorescent micelles into tumors. Using optical imaging with NIR phosphorescent nanomicelles, detection of smaller, visually undetectable tumors has also been demonstrated.
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