Paramagnetic levitational assembly of hydrogels.
Paramagnetic levitational assembly of hydrogels.
复制标题
DOI：
10.1002/adma.201200285
复制
发表时间：
2013-02-25
影响因子：
29.4
通讯作者：
Demirci, Utkan
中科院分区：
文献类型：
--
作者：
Tasoglu, Savas;Kavaz, Doga;Gurkan, Umut Atakan;Guven, Sinan;Chen, Pu;Zheng, Reila;Demirci, Utkan
关键词：
Tissues and organs are composed of repeating functional units.[1–3, 48] Among these repeating basic cellular structures are the hexagonal lobule in liver, the nephron in kidney, and the islets in pankreas.[4–6] Tissue engineering aims to mimic the native 3D tissue architecture.[7, 47] Engineered tissue constructs have broad applications in regenerative medicine [8–10] and physiological systems for pharmaceutical research.[11] In vivo, cells are surrounded by extracellular matrix (ECM), and exist in well-defined spatial organization with neighboring cells. Tissue functionality depends on these components, their interactions and relative spatial locations.[12–14] A high level of control over 3D tissue architecture has applications in identifying structure–function relationships in order to resolve underlying mechanisms and to model biological phenomena and diseases in vitro. Scaffolding and existing top-down approaches offer limited control over recapitulating 3D architecture and complex features of native tissues.[15, 16] On the other hand, bottom-up methods aim to generate complex tissue structures by assembling building blocks, such as cell encapsulating microscale hydrogels.[4, 17–22]Although mechanisms such as stirring/agitation, self-assembly,[23] multilayer photopatterning,[24] and hydrophilic–hydrophobic interactions [17] have been utilized in hydrogel assembly, these methods have not been broadly integrated with practical applications.[25–27] Moreover, assembly of hydrogels with control over the 3D microarchitecture remains as a challenge. For instance, assembled hydrogel architectures can be created employing multilayer photopatterning and microfluidic-directed assembly.[28, 29] However, they require peripheral equipment and long processing times.[28, 29] Hence, there is a need for simple 3D hydrogel assembly methods.[25, 30]
登录
查看更多内容
影响因子：
9
作者：
Jakab K;Norotte C;Marga F;Murphy K;Vunjak-Novakovic G;Forgacs G
通讯作者：
Forgacs G
影响因子：
14
作者：
Bryant, Stephanie J.;Cuy, Janet L.;Ratner, Buddy D.
通讯作者：
Ratner, Buddy D.
DOI：
10.1073/pnas.0801866105
发表时间：
2008-07-15
影响因子：
11.1
作者：
Du, Yanan;Lo, Edward;Khademhosseini, Ali
通讯作者：
Khademhosseini, Ali
影响因子：
--
作者：
Alsberg, Eben;Feinstein, Efraim;Ingber, Donald E.
通讯作者：
Ingber, Donald E.
影响因子：
56.9
作者：
LANGER, R;VACANTI, JP
通讯作者：
VACANTI, JP