Dopamine signaling in the nucleus accumbens core mediates latent inhibition.
Dopamine signaling in the nucleus accumbens core mediates latent inhibition.
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DOI：
10.1038/s41593-022-01126-1
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发表时间：
2022-08
影响因子：
25
通讯作者：
Calipari, Erin S.
中科院分区：
文献类型：
--
作者：
Kutlu, Munir Gunes;Zachry, Jennifer E.;Melugin, Patrick R.;Tat, Jennifer;Cajigas, Stephanie;Isiktas, Atagun U.;Patel, Dev D.;Siciliano, Cody A.;Schoenbaum, Geoffrey;Sharpe, Melissa J.;Calipari, Erin S.
Studies investigating the neural mechanisms by which associations between cues and predicted outcomes control behavior often use associative-learning frameworks to understand the neural control of behavior. These frameworks do not always account for the full range of effects that novelty can have on behavior and future associative learning. Here, in mice, we show that dopamine in the nucleus accumbens (NAc) core is evoked by novel, neutral stimuli, and the trajectory of this response over time tracked habituation to these stimuli. Habituation to novel cues prior to associative learning reduced future associative learning, a phenomenon known as latent inhibition. Crucially, trial-by-trial dopamine response patterns tracked this phenomenon. Optogenetic manipulation of dopamine responses to the cue during the habituation period bidirectionally influenced future associative learning. Thus, dopamine signaling in the NAc core has a causal role in novelty-based learning in a way that cannot be predicted based on purely associative factors.
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DOI：
10.1016/j.cub.2021.05.056
发表时间：
2021-08-23
期刊：
Current biology : CB
影响因子：
--
作者：
Jacob PF;Vargas-Gutierrez P;Okray Z;Vietti-Michelina S;Felsenberg J;Waddell S
通讯作者：
Waddell S
影响因子：
1.4
作者：
AYRES, JJB;PHILBIN, D;REDLINGER, E
通讯作者：
REDLINGER, E
影响因子：
2.7
作者：
DELACASA, G;LUBOW, RE
通讯作者：
LUBOW, RE
影响因子：
22.4
作者：
LUBOW, RE
通讯作者：
LUBOW, RE
影响因子：
9.2
作者：
Kutlu, Munir Gunes;Zachry, Jennifer E.;Melugin, Patrick R.;Cajigas, Stephanie A.;Chevee, Maxime F.;Kelly, Shannon J.;Kutlu, Banu;Tian, Lin;Siciliano, Cody A.;Calipari, Erin S.
通讯作者：
Calipari, Erin S.