Dopamine release in the nucleus accumbens core signals perceived saliency.
Dopamine release in the nucleus accumbens core signals perceived saliency.
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DOI：
10.1016/j.cub.2021.08.052
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发表时间：
2021-11-08
期刊：
影响因子：
9.2
通讯作者：
Calipari, Erin S.
中科院分区：
文献类型：
--
作者：
Kutlu, Munir Gunes;Zachry, Jennifer E.;Melugin, Patrick R.;Cajigas, Stephanie A.;Chevee, Maxime F.;Kelly, Shannon J.;Kutlu, Banu;Tian, Lin;Siciliano, Cody A.;Calipari, Erin S.
一大批工作的目标是定义支配伏隔核的多巴胺能投射所编码的精确信息。流行的模型基于奖励预测误差(RPE)理论，该理论中，多巴胺通过编码预测和结果之间的感知误差来更新奖励和预测线索之间的关联。然而，RPE不能描述与多巴胺有千丝万缕联系的多种现象，例如由厌恶和中性刺激驱动的行为。我们将一系列行为任务与直接的、亚秒级的小鼠伏隔核(NAC)多巴胺监测、机器学习、计算建模和光遗传操作相结合，以描述多种意外情况下的行为和相关的多巴胺释放模式，并得到不同效价结果的强化。我们表明，多巴胺的释放只在部分学习场景中符合RPE预测，但适合跨条件的价独立感知显著编码。总之，我们为伏隔区多巴胺在行为控制中的释放提供了一个扩展的、全面的框架。
A large body of work has aimed to define the precise information encoded by dopaminergic projections innervating the nucleus accumbens. Prevailing models are based on reward prediction error (RPE) theory where dopamine updates associations between rewards and predictive cues by encoding perceived errors between predictions and outcomes. However, RPE cannot describe multiple phenomena to which dopamine is inextricably linked, such as behavior driven by aversive and neutral stimuli. We combined a series of behavioral tasks with direct, subsecond dopamine monitoring in the nucleus accumbens (NAc) of mice, machine learning, computational modeling, and optogenetic manipulations to describe behavior and related dopamine release patterns across multiple contingencies reinforced by differentially valenced outcomes. We show that dopamine release only conforms to RPE predictions in a subset of learning scenarios but fits valence-independent perceived saliency encoding across conditions. Together, we provide an extended, comprehensive framework for accumbal dopamine release in behavioral control.
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影响因子：
25
作者：
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通讯作者：
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影响因子：
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DOI：
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影响因子：
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