Embryonic macrophages function during early life to determine invariant natural killer T cell levels at barrier surfaces.
Embryonic macrophages function during early life to determine invariant natural killer T cell levels at barrier surfaces.
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DOI：
10.1038/s41590-021-00934-0
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发表时间：
2021-06
影响因子：
30.5
通讯作者：
Blumberg RS
中科院分区：
文献类型：
--
作者：
Gensollen T;Lin X;Zhang T;Pyzik M;See P;Glickman JN;Ginhoux F;Waldor M;Salmi M;Rantakari P;Blumberg RS
人们越来越认识到，黏膜组织内的免疫发育受生命早期环境因素的控制。然而，这些过程的这种时间和区域限制性治理背后的细胞机制尚不清楚。在这里，我们揭示了结肠内免疫发育的胸腺外途径，该途径由胚胎而非骨髓来源的巨噬细胞控制，它决定了这些器官接受不变性自然杀伤T （iNKT）细胞并允许它们在当地定居的能力。因此，胎儿源性巨噬细胞的早期扰动导致粘膜iNKT细胞的持续减少，并与晚年对iNKT细胞相关的粘膜疾病的易感性或抵抗力有关。这些研究揭示了宿主发育程序是由不同的巨噬细胞编排的，受微生物群调节，并揭示了巨噬细胞在胎儿生命中出现的重要产后功能。
It is increasingly recognized that immune development within mucosal tissues is under the control of environmental factors during early life. However, the cellular mechanisms that underlie such temporally and regionally restrictive governance of these processes is unclear. Here, we uncover an extrathymic pathway of immune development within the colon that is controlled by embryonic, but not bone-marrow derived, macrophages which determines the ability of these organs to receive invariant natural killer T (iNKT) cells and allow them to establish local residency. Consequently, early life perturbations of fetal-derived macrophages result in persistent decreases of mucosal iNKT cells and is associated with later life susceptibility or resistance to iNKT cell associated mucosal disorders. These studies uncover a host developmental program orchestrated by ontogenically distinct macrophages that is regulated by microbiota and reveal an important post-natal function of macrophages that emerge in fetal life.
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影响因子：
30.3
作者：
Cahenzli J;Köller Y;Wyss M;Geuking MB;McCoy KD
通讯作者：
McCoy KD
DOI：
10.1126/science.1219328
发表时间：
2012-04-27
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Olszak T;An D;Zeissig S;Vera MP;Richter J;Franke A;Glickman JN;Siebert R;Baron RM;Kasper DL;Blumberg RS
通讯作者：
Blumberg RS
DOI：
10.1093/bioinformatics/btu638
发表时间：
2015-01-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Anders S;Pyl PT;Huber W
通讯作者：
Huber W
DOI：
10.1084/jem.20130903
发表时间：
2013-09-23
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Schreiber HA;Loschko J;Karssemeijer RA;Escolano A;Meredith MM;Mucida D;Guermonprez P;Nussenzweig MC
通讯作者：
Nussenzweig MC
影响因子：
7.8
作者：
Chakravarti, S;Magnuson, T;Lass, JH;Jepsen, KJ;LaMantia, C;Carroll, H
通讯作者：
Carroll, H