Electrophysiological characterisation of central sensitisation in canine spontaneous osteoarthritis.
Electrophysiological characterisation of central sensitisation in canine spontaneous osteoarthritis.
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DOI：
10.1097/j.pain.0000000000001336
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发表时间：
2018-11
期刊：
影响因子：
7.4
通讯作者：
Murrell JC
中科院分区：
文献类型：
--
作者：
Hunt JR;Goff M;Jenkins H;Harris J;Knowles TG;Lascelles BDX;Enomoto M;Mendl M;Whay HR;Murrell JC
在男性，中枢致敏（CS）有助于骨关节炎（OA）的疼痛。自发性OA犬也可能表现为CS。电生理反射测量比行为评估更客观，可用于评估临床前和临床研究中的CS。假设患OA的狗会表现出表明CS的电生理特征，与弥漫性有害抑制控制（DNIC）减少有关。117只客户养的狗被招募到这项研究中。记录46只OA犬、29只接受非甾体抗炎药（OANSAID）的OA犬和27只品种和体重匹配的对照犬在阿法索龙麻醉期间后肢伤害性戒断反射（NWR）阈值、刺激反应和时间汇总特征。在12只对照犬和11只OA犬中，通过对侧前肢施加机械条件刺激来评估DNIC的疗效。与对照组相比，OA组的NWR阈值更高（p = 0.02）。与OA （p < 0.001）和对照组（p < 0.001）相比，OANSAID犬的刺激反应特征显示出增强的反应。时间累计显示，与对照动物相比，OA组（p < 0.001）和OANSAID组（p = 0.005）的c纤维介导的反应都被夸大了。条件反射刺激的应用导致OA动物和对照动物的测试反射反应被抑制（p < 0.001）；对照动物与OA相比表现出更大的抑制作用（p = 0.0499）。这些数据为自发性OA犬的神经生理变化提供了与CS一致的证据，并证明犬OA与DNIC降低有关。
In man, central sensitisation (CS) contributes to the pain of osteoarthritis (OA). Dogs with spontaneous OA may also exhibit CS. Electrophysiological reflex measurements are more objective than behavioural assessments, and can be used to evaluate CS in preclinical and clinical studies. It was hypothesised that dogs suffering from OA would exhibit electrophysiological characteristics indicative of CS, associated with reduced diffuse noxious inhibitory controls (DNIC). 117 client owned dogs were recruited to the study. Hindlimb nociceptive withdrawal reflex (NWR) thresholds, stimulus response, and temporal summation characteristics were recorded, during alfaxalone anaesthesia, from 46 OA dogs, 29 OA dogs receiving non-steroidal anti-inflammatory drugs (OANSAID), and 27 breed- and weight-matched control dogs. Efficacy of DNIC was evaluated in 12 control and 11 of the OA dogs, by application of a mechanical conditioning stimulus to the contralateral forelimb. NWR thresholds were higher in OA compared with control dogs (p = 0.02). Stimulus response characteristics demonstrated an augmented response in OANSAID dogs compared with OA (p < 0.001) and control (p < 0.001) dogs. Temporal summation demonstrated exaggerated C-fibre mediated responses in both OA (p < 0.001) and OANSAID (p = 0.005) groups, compared with control animals. Conditioning stimulus application resulted in inhibition of test reflex responses in both OA and control animals (p < 0.001); control animals demonstrated greater inhibition compared with OA (p = 0.0499). These data provide evidence of neurophysiological changes consistent with CS in dogs with spontaneous OA, and demonstrate that canine OA is associated with reduced DNIC.
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影响因子：
7.4
作者：
Knazovicky D;Helgeson ES;Case B;Gruen ME;Maixner W;Lascelles BDX
通讯作者：
Lascelles BDX
影响因子：
1.7
作者：
Bergadano, Alessandra;Andersen, Ole K.;Spadavecchia, Claudia
通讯作者：
Spadavecchia, Claudia
影响因子：
3.4
作者：
Harris, John
通讯作者：
Harris, John
影响因子：
7
作者：
Neogi, T.
通讯作者：
Neogi, T.
影响因子：
1.8
作者：
Brown, Dorothy Cimino
通讯作者：
Brown, Dorothy Cimino