FGFR-2 and Epithelial-Mesenchymal Transition in Endometrial Cancer.
FGFR-2 and Epithelial-Mesenchymal Transition in Endometrial Cancer.
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DOI：
10.3390/jcm11185416
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发表时间：
2022-09-15
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
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作者：
背景资料。目前，EC的分期是基于WHO的保守标准，只考虑腺体形成的百分比。最近由癌症基因组图谱(TCGA)提出的EC的分子亚型代表了精确的基于分子的患者分类的一个里程碑。本研究旨在探讨成纤维细胞生长因子受体-2(FGFR-2)在子宫内膜上皮-间充质转化(EMT)过程中的作用及其与子宫内膜癌去分化的关系。方法：研究方法。103例确诊为EC的白人女性患者纳入我们的研究。为了进行分析，我们进行了下一代测序和E-钙粘蛋白、β-连环蛋白和波形蛋白的免疫组织化学分析。结果。肿瘤分级与左心室指数(p=0.0338)、波形蛋白表达(p=0.000)、肿瘤萌发(p=0.000)和E-钙粘附素缺乏(p=0.0028)密切相关。在TNM/FIGO阶段进展方面也注意到了类似的意见。在FGFR-2突变方面，我们发现以下相关p值：LVI(p=0.069)、Vimentin表达(p=0.000)、肿瘤萌芽(p=0.000)、E-钙粘素缺失(p=0.000)、rFS(p=0.032)、ECSS(p=0.047)。结论。FGFR-2是影响EMT的重要因素。
Background. At present, EC staging is based on the WHO conservative criteria, which only consider the percentage of gland formation. The molecular subgrouping of EC recently proposed by the Cancer Genome Atlas (TCGA) represents a milestone in precise molecular-based patient triage. The present study aimed to investigate the influence of FGFR-2 on the epithelial–mesenchymal transition (EMT) and whether it can lead to endometrial cancer dedifferentiation. Methods. One hundred and three White female patients with confirmed EC were enrolled in our research. For the analysis, we performed next-generation sequencing and immunohistochemical analyses of E-cadherin, β-catenin, and vimentin. Results. Tumor grade progression was closely correlated with LVI (p = 0.0338), expression of vimentin (p = 0.000), tumor budding (p = 0.000), and lack of E-cadherin (p = 0.0028). Similar observations were noted with regard to TNM/FIGO stage progression. In terms of FGFR-2 mutation, we found the following correlation p-values: LVI (p = 0.069), expression of vimentin (p = 0.000), tumor budding (p = 0.000), and lack of E-cadherin (p = 0.000), RFS (p = 0.032), ECSS (p = 0.047). Conclusions. FGFR-2 is the important factor influencing on EMT.
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DOI：
10.3390/diagnostics12071737
发表时间：
2022-07-18
期刊：
Diagnostics (Basel, Switzerland)
影响因子：
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作者：
通讯作者：
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影响因子：
1.8
作者：
Haase, Matthias;Thiel, Anne;Ehlers, Margret
通讯作者：
Ehlers, Margret
影响因子：
5.2
作者：
Cruz RGB;Madden SF;Richards CE;Vellanki SH;Jahns H;Hudson L;Fay J;O'Farrell N;Sheehan K;Jirström K;Brennan K;Hopkins AM
通讯作者：
Hopkins AM
DOI：
10.3390/ijerph191610403
发表时间：
2022-08-21
影响因子：
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作者：
Adamczyk-Gruszka, Olga;Horecka-Lewitowicz, Agata;Gruszka, Jakub;Wawszczak-Kasza, Monika;Strzelecka, Agnieszka;Lewitowicz, Piotr
通讯作者：
Lewitowicz, Piotr
影响因子：
254.7
作者：
Siegel, Rebecca;Naishadham, Deepa;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin