SARS-CoV-2 infection generates tissue-localized immunological memory in humans.
SARS-CoV-2 infection generates tissue-localized immunological memory in humans.
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DOI：
10.1126/sciimmunol.abl9105
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发表时间：
2021-11-19
影响因子：
24.8
通讯作者：
Farber DL
中科院分区：
文献类型：
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作者：
Poon MML;Rybkina K;Kato Y;Kubota M;Matsumoto R;Bloom NI;Zhang Z;Hastie KM;Grifoni A;Weiskopf D;Wells SB;Ural BB;Lam N;Szabo PA;Dogra P;Lee YS;Gray JI;Bradley MC;Brusko MA;Brusko TM;Saphire EO;Connors TJ;Sette A;Crotty S;Farber DL
对SARS-CoV-2感染的适应性免疫反应在血液中得到了广泛的表征;然而，大多数保护性免疫功能必须在组织中完成。在这里，我们报告从SARS-CoV-2血清阳性器官捐献者（年龄10 - 74岁）的检查，CD 4 + T，CD 8 + T，和B细胞的记忆产生的响应感染存在于骨髓，脾，肺，和多个淋巴结（LN）感染后长达6个月。肺和肺相关淋巴结是SARS-CoV-2特异性记忆T和B细胞最常见的部位，在所有部位，循环和组织驻留记忆T和B细胞之间存在显著相关性。我们进一步确定了SARS-CoV-2特异性生殖中心在肺相关LN感染后6个月。SARS-CoV-2特异性滤泡辅助性T细胞在肺相关淋巴结和肺中也很丰富。总之，这些结果表明，针对SARS-CoV-2的细胞和体液免疫记忆的局部组织协调，用于针对未来感染挑战的位点特异性保护。SARS-CoV 2特异性记忆细胞在感染后数月仍存在于多个部位，特别是在肺和相关淋巴结中。
Adaptive immune responses to SARS-CoV-2 infection have been extensively characterized in blood; however, most functions of protective immunity must be accomplished in tissues. Here, we report from examination of SARS-CoV-2 seropositive organ donors (ages 10 – 74) that CD4+ T, CD8+ T, and B cell memory generated in response to infection is present in bone marrow, spleen, lung, and multiple lymph nodes (LNs) for up to 6 months post-infection. Lungs and lung-associated LNs were the most prevalent sites for SARS-CoV-2-specific memory T and B cells, with significant correlations between circulating and tissue-resident memory T and B cells in all sites. We further identified SARS-CoV-2-specific germinal centers in the lung-associated LNs up to 6 months post-infection. SARS-CoV-2-specific follicular helper T cells were also abundant in lung-associated LNs and lungs. Together, the results indicate local tissue coordination of cellular and humoral immune memory against SARS-CoV-2 for site-specific protection against future infectious challenges. SARS-CoV2-specific memory cells persist in multiple sites months after infection, and particularly in lungs and associated lymph nodes.
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影响因子：
64.8
作者：
Gaebler C;Wang Z;Lorenzi JCC;Muecksch F;Finkin S;Tokuyama M;Cho A;Jankovic M;Schaefer-Babajew D;Oliveira TY;Cipolla M;Viant C;Barnes CO;Bram Y;Breton G;Hägglöf T;Mendoza P;Hurley A;Turroja M;Gordon K;Millard KG;Ramos V;Schmidt F;Weisblum Y;Jha D;Tankelevich M;Martinez-Delgado G;Yee J;Patel R;Dizon J;Unson-O'Brien C;Shimeliovich I;Robbiani DF;Zhao Z;Gazumyan A;Schwartz RE;Hatziioannou T;Bjorkman PJ;Mehandru S;Bieniasz PD;Caskey M;Nussenzweig MC
通讯作者：
Nussenzweig MC
T细胞和抗体动力学描述了介导共证疗法个体中介导长期免疫反应的SARS-COV-2肽。
影响因子：
17.1
作者：
Bilich T;Nelde A;Heitmann JS;Maringer Y;Roerden M;Bauer J;Rieth J;Wacker M;Peter A;Hörber S;Rachfalski D;Märklin M;Stevanović S;Rammensee HG;Salih HR;Walz JS
通讯作者：
Walz JS
影响因子：
64.5
作者：
Dogra, Pranay;Rancan, Chiara;Farber, Donna L.
通讯作者：
Farber, Donna L.
DOI：
10.1111/ajt.14434
发表时间：
2018-01
期刊：
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
影响因子：
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作者：
Carpenter DJ;Granot T;Matsuoka N;Senda T;Kumar BV;Thome JJC;Gordon CL;Miron M;Weiner J;Connors T;Lerner H;Friedman A;Kato T;Griesemer AD;Farber DL
通讯作者：
Farber DL
DOI：
10.1038/nri3567
发表时间：
2014-01
期刊：
Nature reviews. Immunology
影响因子：
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作者：
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