Evolution of transcription factor function as a mechanism for changing metazoan developmental gene regulatory networks.
Evolution of transcription factor function as a mechanism for changing metazoan developmental gene regulatory networks.
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DOI：
10.1186/2041-9139-6-3
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发表时间：
2015
期刊：
影响因子：
4.1
通讯作者：
Hinman VF
中科院分区：
文献类型：
--
作者：
Cheatle Jarvela AM;Hinman VF
动物在发育过程中采取的形式是由基因调控网络（GRNs）指导的。发育中的grn解释母体沉积的分子和外部提供的信号来指导细胞命运的决定，最终导致生物体中器官和组织的排列。对这些网络的基因编码修改产生了今天存在的广泛的后生动物多样性。大多数关于GRN进化的研究都集中在顺式调控DNA的变化上，历史上的理论认为，与这些顺式调控模块（CRMs）结合的转录因子的变化很少参与这一过程。越来越多的证据表明，转录因子编码区的变化在发育基因调控网络的进化中发挥的作用比原先想象的要大得多。正如顺式调控改变利用模块化结合位点组成和组织特异性模块来避免多效性一样，转录因子编码区也主要以限制功能作用背景的方式进化。在这里，我们回顾了最近在进化与发展领域（Evo-Devo）导致这种意想不到的变化的工作，并考虑了这些研究对我们对发育过程进化的理解的影响。
The form that an animal takes during development is directed by gene regulatory networks (GRNs). Developmental GRNs interpret maternally deposited molecules and externally supplied signals to direct cell-fate decisions, which ultimately leads to the arrangements of organs and tissues in the organism. Genetically encoded modifications to these networks have generated the wide range of metazoan diversity that exists today. Most studies of GRN evolution focus on changes to cis-regulatory DNA, and it was historically theorized that changes to the transcription factors that bind to these cis-regulatory modules (CRMs) contribute to this process only rarely. A growing body of evidence suggests that changes to the coding regions of transcription factors play a much larger role in the evolution of developmental gene regulatory networks than originally imagined. Just as cis-regulatory changes make use of modular binding site composition and tissue-specific modules to avoid pleiotropy, transcription factor coding regions also predominantly evolve in ways that limit the context of functional effects. Here, we review the recent works that have led to this unexpected change in the field of Evolution and Development (Evo-Devo) and consider the implications these studies have had on our understanding of the evolution of developmental processes.
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DOI：
10.1126/science.1162327
发表时间：
2009-06-26
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Badis G;Berger MF;Philippakis AA;Talukder S;Gehrke AR;Jaeger SA;Chan ET;Metzler G;Vedenko A;Chen X;Kuznetsov H;Wang CF;Coburn D;Newburger DE;Morris Q;Hughes TR;Bulyk ML
通讯作者：
Bulyk ML
影响因子：
7
作者：
Blekhman, Ran;Marioni, John C.;Gilad, Yoav
通讯作者：
Gilad, Yoav
影响因子：
46.9
作者：
Berger, Michael F.;Philippakis, Anthony A.;Bulyk, Martha L.
通讯作者：
Bulyk, Martha L.
影响因子：
2.6
作者：
DuBuc, Timothy Q.;Ryan, Joseph F.;Martindale, Mark Q.
通讯作者：
Martindale, Mark Q.
影响因子：
11.4
作者：
DUBOULE, D;DOLLE, P
通讯作者：
DOLLE, P