Associations between race, APOE genotype, cognition, and mortality among urban middle-aged white and African American adults.
Associations between race, APOE genotype, cognition, and mortality among urban middle-aged white and African American adults.
复制标题
城市中年白色和非裔美国人的种族、APOE基因型、认知和死亡率之间的关系
DOI：
10.1038/s41598-021-98117-2
复制
发表时间：
2021-10-06
影响因子：
4.6
通讯作者：
Beydoun MA
中科院分区：
文献类型：
--
作者：
Weiss J;Hossain S;Maldonado AI;Shen B;Beydoun HA;Kivimaki M;Evans MK;Zonderman AB;Beydoun MA
我们在一项对2346名中年白色和非洲裔美国成年人（基线年龄30-64岁）的纵向研究中，研究了认知与死亡率之间的关联，以及这些关系如何因种族和载脂蛋白E（APOE）基因型而变化。基线认知跨越整体精神状态，以及使用主成分分析获得的几个领域（PCA; PCA 1：言语记忆/流畅性; PCA 2：注意力/工作记忆; PCA 3：执行功能/视觉空间能力）。考克斯回归模型评估认知与全因和心血管疾病（CVD）死亡率之间的关联。测试了认知与APOE 2和APOE 4等位基因剂量之间的相互作用，种族是关键效应修饰符。较高的APOE 4剂量与CVD死亡率增加相关（每个等位基因的风险比[HR]= 1.37; 95% CI 1.01-1.86，p = 0.041）; APOE 2剂量与CVD死亡率的相关性不显著（HR = 0.60; 95% CI 0.35-1.03，p = 0.065）。较高的PCA 3与较低的全因（HR = 0.93; 95% CI 0.87-0.99，p = 0.030）和CVD（HR = 0.85; 95% CI 0.77-0.95，p = 0.001）死亡风险相关，后者在白人中更为明显。PCA 2与APOE 2剂量协同作用，降低全因死亡率（PCA 2 × APOE 2：− 0.33 ± 0.13，p = 0.010）和CVD死亡率（PCA 2 × APOE 2：− 0.73 ± 0.31，p = 0.019）的风险。总之，更强的执行功能/视觉空间能力与CVD特异性死亡率降低相关，尤其是在白人中。更大的“注意力/工作记忆”加上更高的APOE 2剂量与降低全因和CVD死亡风险有关。
We examined associations between cognition and mortality and how these relationships vary by race and Apolipoprotein E (APOE) genotype, in a longitudinal study of 2346 middle-aged White and African American adults (30–64 years at baseline) from the Healthy Aging in Neighborhoods of Diversity across the Life Span cohort study. Baseline cognition spanned global mental status, and several domains obtained using principal components analysis (PCA; PCA1: verbal memory/fluency; PCA2: attention/working memory; PCA3: executive function/visuo-spatial abilities). Cox regression models evaluated associations between cognition and all-cause and cardiovascular disease (CVD)-mortality. Interactions between cognition and APOE2 as well as APOE4 allelic dose were tested, and race was a key effect modifier. Higher APOE4 dose was associated with increased CVD-mortality (hazard ratio [HR] per allele = 1.37; 95% CI 1.01–1.86, p = 0.041); APOE2 dosage’s association with CVD-mortality was non-significant (HR = 0.60; 95% CI 0.35–1.03, p = 0.065). Higher PCA3 was associated with lower all-cause (HR = 0.93; 95% CI 0.87–0.99, p = 0.030) and CVD (HR = 0.85; 95% CI 0.77–0.95, p = 0.001) mortality risks, the latter association being more pronounced among Whites. PCA2 interacted synergistically with APOE2 dosage, reducing risks for all-cause mortality (PCA2 × APOE2: − 0.33 ± 0.13, p = 0.010) and CVD mortality (PCA2 × APOE2: − 0.73 ± 0.31, p = 0.019). In conclusion, greater executive function/visuo-spatial abilities were associated with reduced CVD-specific mortality, particularly among Whites. Greater “attention/working memory” coupled with higher APOE2 dosage was linked with reduced all-cause and CVD mortality risks.
登录
查看更多内容
影响因子：
4.2
作者：
Beydoun MA;Boueiz A;Abougergi MS;Kitner-Triolo MH;Beydoun HA;Resnick SM;O'Brien R;Zonderman AB
通讯作者：
Zonderman AB
DOI：
10.1186/s13195-021-00855-y
发表时间：
2021-06-30
期刊：
Alzheimer's research & therapy
影响因子：
--
作者：
Beydoun MA;Weiss J;Beydoun HA;Hossain S;Maldonado AI;Shen B;Evans MK;Zonderman AB
通讯作者：
Zonderman AB
影响因子：
4.7
作者：
Appiah, Duke;Baumgartner, Richard N.
通讯作者：
Baumgartner, Richard N.
影响因子：
6.3
作者：
Beydoun, May A.;Beydoun, Hind A.;Zonderman, Alan B.
通讯作者：
Zonderman, Alan B.
影响因子：
2.1
作者：
Ewbank, DC
通讯作者：
Ewbank, DC