Repeated cycles of chronic intermittent ethanol exposure in mice increases voluntary ethanol drinking and ethanol concentrations in the nucleus accumbens.
Repeated cycles of chronic intermittent ethanol exposure in mice increases voluntary ethanol drinking and ethanol concentrations in the nucleus accumbens.
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DOI：
10.1007/s00213-008-1324-3
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发表时间：
2009-01
影响因子：
3.4
通讯作者：
Becker, Howard C.
中科院分区：
文献类型：
--
作者：
Griffin, William C., III;Lopez, Marcelo F.;Yanke, Amy B.;Middaugh, Lawrence D.;Becker, Howard C.
本研究考察了乙醇依赖和非依赖C57BL/6J小鼠伏隔核中自愿乙醇消耗与乙醇浓度之间的关系。给小鼠提供两瓶乙醇选择，有限获取模式和用舔液计监测完成行为。在基线摄入量稳定后，小鼠通过吸入慢性间歇乙醇（EtOH组）或空气（CTL组）暴露（16小时/天，持续4天），然后恢复饮酒。通过微透析程序测量自愿饮酒期间的脑乙醇水平，并将其与慢性间歇性乙醇蒸气暴露期间产生的脑乙醇浓度进行比较。在慢性间歇乙醇暴露的重复周期中，自愿乙醇消耗逐渐增加，但在CTL小鼠中保持不变。舔舐模式分析表明，与CTL小鼠相比，EtOH小鼠消耗乙醇的速度更快。与CTL小鼠相比，EtOH小鼠更大更快的乙醇摄入速度产生了更高的峰值脑乙醇浓度，这些水平与慢性间歇乙醇暴露时产生的水平相似。这些结果表明，在这种依赖和复发饮酒模型中，依赖小鼠相对于非依赖对照组表现出更强的自愿乙醇消耗，从而产生与慢性间歇性乙醇暴露相似的血液和脑乙醇浓度。
This study examined the relationship between voluntary ethanol consumption and ethanol concentrations measured in the nucleus accumbens of ethanol dependent and non-dependent C57BL/6J mice. Mice were offered ethanol in a 2-bottle choice, limited access paradigm and consummatory behavior was monitored with lickometers. After baseline intake stabilized, mice received chronic intermittent ethanol (EtOH group) or air (CTL group) exposure by inhalation (16 hr/day for 4 days) and then resumed drinking. Brain ethanol levels during voluntary drinking were measured by microdialysis procedures and compared to brain ethanol concentrations produced during chronic intermittent ethanol vapor exposure. Voluntary ethanol consumption progressively increased over repeated cycles of chronic intermittent ethanol exposure but remained unchanged in CTL mice. Analysis of lick patterns indicated EtOH mice consumed ethanol at a faster rate compared to CTL mice. The greater and faster rate of ethanol intake in EtOH mice produced higher peak brain ethanol concentrations compared to CTL mice and these levels were similar to levels produced during chronic intermittent ethanol exposure. These results show that in this model of dependence and relapse drinking, dependent mice exhibit enhanced voluntary ethanol consumption relative to non-dependent controls, which consequently produces blood and brain ethanol concentrations similar to those experienced during chronic intermittent ethanol exposure.
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影响因子：
2.3
作者：
DESROCHES, D;OREVILLO, C;VERINA, D
通讯作者：
VERINA, D
影响因子：
2.9
作者：
Griffin, William C., III;Middaugh, Lawrence D.;Becker, Howard C.
通讯作者：
Becker, Howard C.
影响因子：
4.7
作者：
Robinson, DL;Lara, JA;Gonzales, RA
通讯作者：
Gonzales, RA
影响因子：
4.3
作者：
Yadav, Sanjay;Dhawan, Alok;Parmar, Devendra
通讯作者：
Parmar, Devendra
DOI：
10.1097/01.alc.0000179413.82308.6b
发表时间：
2005-09-01
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Ford, Matthew M;Nickel, Jeffrey D;Finn, Deborah A
通讯作者：
Finn, Deborah A