Phosphorylated proteins and control over apatite nucleation, crystal growth, and inhibition.
Phosphorylated proteins and control over apatite nucleation, crystal growth, and inhibition.
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DOI：
10.1021/cr0782729
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发表时间：
2008-11
期刊：
影响因子：
62.1
通讯作者：
Veis, Arthur
中科院分区：
文献类型：
--
作者：
George, Anne;Veis, Arthur
生物体能够诱导多种矿物质的结晶和沉积，但脊椎动物主要利用磷酸钙在正常情况下在骨、牙本质和牙釉质中以及在病理性异位矿物质沉积中构建其矿物质相。在所有情况下，矿物的主要形式是碳酸磷灰石。然而，特定组织或器官中的矿化程度是相当可变的，并且矿物晶体的微晶大小、晶体形状以及填充和组织也可以是可变的。很明显，同样的物理化学原理必须适用于所有生物，但同样清楚的是，有机体必须严格调节矿物形成的局部环境。这是一个本质上复杂的问题，因为骨和牙本质的矿物晶体形成于细胞外的细胞外基质中，细胞外基质是该过程的最终调节剂。多年来对这一复杂问题的研究已经导致了普遍的共识，即细胞控制的矿化过程开始于制造有机结构，在该有机结构内，或在其上的隔室表面，可以引发矿物晶体。细胞分泌和组织大分子结构，这些结构决定了随后启动和生长的晶体的最终特性和取向，但一般来说，这些结构本身不具有启动矿化的能力。初始晶体成核事件取决于结构大分子与另一组分泌的相互作用大分子的相互作用，所述相互作用大分子特异性地位于结构框架上。这些相互作用的分子是双重相互作用的，特异性地结合到
Living organisms are capable of inducing the crystallization and deposition of a wide variety of minerals, 1 but the vertebrates mainly utilize the calcium phosphates in constructing their mineral phases in both normal circumstances in bone, dentin, and tooth enamel and in pathological ectopic mineral deposits. The predominant form of the mineral in all situations is as carbonated apatite. However, the extent of mineralization in a particular tissue or organ is quite variable and crystallite size, crystal shape, and packing and organization of the mineral crystals may also be variable. It is clear that the same physical chemical principles must apply to all, but it is equally clear that the organism must tightly regulate the local environment where the mineral is formed. This is an intrinsically complex problem because the mineral crystals of bone and dentin form in the extracellular matrix, external to the cells, which are the ultimate regulators of the process.Years of study of this complex set of problems has led to the general consensus that the cell-controlled processes of mineralization begin with the manufacture of an organic structure within which, or a compartment surface upon which, the mineral crystals may be initiated. The cells secrete and organize macromolecular structures that determine the ultimate character and orientations of the crystals subsequently initiated and grown, but in general, these structures do not themselves have the capacity to initiate mineralization. The incipient crystal nucleation event depends upon the interaction of the structural macromolecules with another set of secreted interactive macromolecules that locate specifically on the structural framework. These interactive molecules are doubly interactive, binding specifically to the framework on
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影响因子：
3.2
作者：
BIANCO, P;RIMINUCCI, M;ROBEY, PG
通讯作者：
ROBEY, PG
影响因子：
4.2
作者：
Campbell, TM;Wong, WT;Mackie, EJ
通讯作者：
Mackie, EJ
DOI：
10.1111/j.1749-6632.1995.tb44615.x
发表时间：
1995-01-01
期刊：
OSTEOPONTIN: ROLE IN CELL SIGNALLING AND ADHESION
影响因子：
--
作者：
BUTLER, WT
通讯作者：
BUTLER, WT
DOI：
10.1111/j.1749-6632.1995.tb44635.x
发表时间：
1995-01-01
期刊：
OSTEOPONTIN: ROLE IN CELL SIGNALLING AND ADHESION
影响因子：
--
作者：
BOSKEY, AL
通讯作者：
BOSKEY, AL
影响因子：
5
作者：
Acebes, C;de la Piedra, C;Herrero-Beaumont, G
通讯作者：
Herrero-Beaumont, G