D-tagatose protects against oleic acid-induced acute respiratory distress syndrome in rats by activating PTEN/PI3K/AKT pathway.
D-tagatose protects against oleic acid-induced acute respiratory distress syndrome in rats by activating PTEN/PI3K/AKT pathway.
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D-诱导蛋白通过激活PTEN/PI3K/AKT途径来预防大鼠油酸诱导的急性呼吸窘迫综合征。
DOI：
10.3389/fimmu.2022.928312
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发表时间：
2022
影响因子：
7.3
通讯作者：
Li, Yongnan
中科院分区：
文献类型：
--
作者：
Huang, Jian;Wang, Bingjie;Tao, Shaoyi;Hu, Yuexia;Wang, Ning;Zhang, Qiaoyun;Wang, Chunhui;Chen, Chen;Gao, Bingren;Cheng, Xingdong;Li, Yongnan
急性呼吸窘迫综合征(ARDS)的特征是肺泡-毛细血管屏障破裂，导致严重的肺泡水肿和炎症。D-塔格糖(TAG)是一种低热量的果糖异构体，具有多种生物活性，其在ARDS中的作用从未被研究过。我们发现，在油酸诱导的ARDS大鼠模型中，TAG对肺组织具有保护作用。17只雄性SD大鼠随机分为3组：假手术组(n=5)、急性呼吸窘迫综合征(ARDS)组(n=6)和TAG+ARDS组(n=6)。治疗组用油酸诱发ARDS，TAG+ARDS组在诱导前3d给予TAG。治疗结束后，通过血气分析和肺大体及组织结构的观察来评价TAG的疗效。结果表明，TAG能显著改善氧合功能，减轻呼吸性酸中毒和炎症反应。TAG还能改善ARDS大鼠的血管通透性，促进肺泡II型细胞分化，维持肺泡结构的稳定。TAG对肺的保护作用可能是通过激活PTEN/PI3K/AKT通路实现的。因此，TAG对油酸诱导的大鼠ARDS具有保护作用，为治疗这种疾病提供了一种新的临床策略。
Acute respiratory distress syndrome (ARDS) is characterized by disruption of the alveolar–capillary barrier, resulting in severe alveolar edema and inflammation. D-tagatose (TAG) is a low-calorie fructose isomer with diverse biological activities whose role in ARDS has never been explored. We found that TAG protects lung tissues from injury in the oleic acid-induced rat model of ARDS. Seventeen male Sprague–Dawley rats were randomly assigned to 3 groups: Sham (n = 5), ARDS (n = 6), and TAG + ARDS (n = 6). The treatment groups were injected with oleic acid to induce ARDS, and the TAG + ARDS group was given TAG 3 days before the induction. After the treatments, the effect of TAG was evaluated by blood gas analysis and observing the gross and histological structure of the lung. The results showed that TAG significantly improved the oxygenation function, reduced the respiratory acidosis and the inflammatory response. TAG also improved the vascular permeability in ARDS rats and promoted the differentiation of alveolar type II cells, maintaining the stability of the alveolar structure. This protective effect of TAG on the lung may be achieved by activating the PTEN/PI3K/AKT pathway. Thus, TAG protects against oleic acid-induced ARDS in rats, suggesting a new clinical strategy for treating the condition.
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DOI：
10.1183/13993003.02978-2020
发表时间：
2021-07
期刊：
The European respiratory journal
影响因子：
--
作者：
Dutra Silva J;Su Y;Calfee CS;Delucchi KL;Weiss D;McAuley DF;O'Kane C;Krasnodembskaya AD
通讯作者：
Krasnodembskaya AD
DOI：
10.1016/s0140-6736(21)00439-6
发表时间：
2021-08-14
期刊：
Lancet (London, England)
影响因子：
--
作者：
Meyer NJ;Gattinoni L;Calfee CS
通讯作者：
Calfee CS
影响因子：
81.5
作者：
Matthay, Michael A.;Zemans, Rachel L.;Calfee, Carolyn S.
通讯作者：
Calfee, Carolyn S.
影响因子：
5
作者：
Durante M;Sgambellone S;Lucarini L;Failli P;Laurino A;Collotta D;Provensi G;Masini E;Collino M
通讯作者：
Collino M
影响因子：
3.6
作者：
Prame Kumar K;Nicholls AJ;Wong CHY
通讯作者：
Wong CHY