JAK/STAT signaling in regulation of innate lymphoid cells: The gods before the guardians.
JAK/STAT signaling in regulation of innate lymphoid cells: The gods before the guardians.
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DOI：
10.1111/imr.12705
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发表时间：
2018-11
影响因子：
8.7
通讯作者：
Sciumè G
中科院分区：
文献类型：
--
作者：
Stabile H;Scarno G;Fionda C;Gismondi A;Santoni A;Gadina M;Sciumè G
通过整合先天细胞介导的早期反应和适应性淋巴细胞终末分化后发生的晚期效应功能，确保对病原体的免疫。在这种情况下，先天性淋巴细胞 (ILC) 和适应性 T 细胞代表了典型效应器功能（包括细胞因子的极化表达和/或细胞毒活性）如何以重叠的方式但不同的时间发生的明显例子。 ILC 提供早期保护的能力依赖于它们平衡的表观遗传状态，这决定了它们快速响应细胞因子并激活信号依赖性转录因子的特定模式的倾向。激活 Janus 激酶 (JAK) 的细胞因子以及信号转导和转录激活因子 (STAT) 通路的成员是淋巴发育的关键调节因子，并维持 T 细胞激活和分化的过程。 JAK/STAT 通路的作用最近已扩展到 ILC 生物学的多个方面。在这里，我们讨论 JAK/STAT 信号如何在免疫反应背景下影响 ILC 发育和效应器功能，强调参与基因表达调节的分子机制，以及在炎症病理学中靶向 JAK/STAT 通路的潜力。
Immunity to pathogens is ensured through integration of early responses mediated by innate cells and late effector functions taking place after terminal differentiation of adaptive lymphocytes. In this context, innate lymphoid cells (ILCs) and adaptive T cells represent a clear example of how prototypical effector functions, including polarized expression of cytokines and/or cytotoxic activity, can occur with overlapping modalities but different timing. The ability of ILCs to provide early protection relies on their poised epigenetic state, which determines their propensity to quickly respond to cytokines and to activate specific patterns of signal-dependent transcription factors. Cytokines activating the Janus kinases (JAKs) and members of the signal transducer and activator of transcription (STAT) pathway are key regulators of lymphoid development and sustain the processes underlying T cell activation and differentiation. The role of the JAK/STAT pathway has been recently extended to several aspects of ILC biology. Here, we discuss how JAK/STAT signals affect ILC development and effector functions in the context of immune responses, highlighting the molecular mechanisms involved in regulation of gene expression, as well as, the potential of targeting the JAK/STAT pathway in inflammatory pathologies.
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影响因子：
30.5
作者：
通讯作者：
--
影响因子：
64.8
作者：
Cella, Marina;Fuchs, Anja;Vermi, William;Facchetti, Fabio;Otero, Karel;Lennerz, Jochen K. M.;Doherty, Jason M.;Mills, Jason C.;Colonna, Marco
通讯作者：
Colonna, Marco
影响因子：
32.4
作者：
Diefenbach, Andreas;Colonna, Marco;Koyasu, Shigeo
通讯作者：
Koyasu, Shigeo
影响因子：
7.8
作者：
Cella M;Colonna M
通讯作者：
Colonna M
影响因子：
32.4
作者：
Bernink, Jochem H.;Krabbendam, Lisette;Spits, Hergen
通讯作者：
Spits, Hergen