Quantifying whole bladder biomechanics using the novel pentaplanar reflected image macroscopy system.
Quantifying whole bladder biomechanics using the novel pentaplanar reflected image macroscopy system.
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使用新型五平面反射图像宏观系统量化整个膀胱生物力学。
DOI：
10.1007/s10237-023-01727-0
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发表时间：
2023-10
影响因子：
3.5
通讯作者：
Tykocki, Nathan R.
中科院分区：
文献类型：
--
作者：
Hennig, Grant;Saxena, Pragya;Broemer, Eli;Herrera, Gerald M.;Roccabianca, Sara;Tykocki, Nathan R.
最佳的膀胱顺应性对于膀胱储存和排尿功能至关重要。通过计算每次压力变化时充盈体积的变化，膀胱顺应性在临床上被用来表征与下尿路功能障碍相关的膀胱壁生物力学特性的变化。但由于这种方法计算的顺应性不考虑膀胱壁的结构或体积，因此它对充盈过程中膀胱壁的力学特性几乎没有洞察力。因此，我们开发了五平面反射图像显微镜(PRIM)：一种新的体外成像方法，可以在膀胱充盈过程中实时准确地计算膀胱壁的应力和拉伸。PRIM系统同时记录膀胱内压、输液量和五个不同视觉平面上的膀胱图像。然后测量壁厚和体积，并用于计算充填过程中的应力和拉伸。正如预测的那样，膀胱壁应力是非线性的；只有当膀胱内压超过 ~ 15 mm Hg时，膀胱壁应力才会相对于拉伸迅速增加。这种计算应力与拉伸顺应性的方法也表明，在不同容量的膀胱中，膀胱壁的力学性能保持相似。这项研究展示了如何根据实际材料特性而不是压力/体积变化来测量、量化和使用壁张力、应力和拉伸来准确定义膀胱壁的生物力学。这种方法特别有助于确定在发生深刻膀胱壁重塑的病理中，如糖尿病和脊髓损伤时，膀胱生物力学的变化是如何改变的。网上版载有补充材料，可在10.1007/s10237-023-01727-0查阅。
Optimal bladder compliance is essential to urinary bladder storage and voiding functions. Calculated as the change in filling volume per change in pressure, bladder compliance is used clinically to characterize changes in bladder wall biomechanical properties that associate with lower urinary tract dysfunction. But because this method calculates compliance without regard to wall structure or wall volume, it gives little insight into the mechanical properties of the bladder wall during filling. Thus, we developed Pentaplanar Reflected Image Macroscopy (PRIM): a novel ex vivo imaging method to accurately calculate bladder wall stress and stretch in real time during bladder filling. The PRIM system simultaneously records intravesical pressure, infused volume, and an image of the bladder in five distinct visual planes. Wall thickness and volume were then measured and used to calculate stress and stretch during filling. As predicted, wall stress was nonlinear; only when intravesical pressure exceeded ~ 15 mmHg did bladder wall stress rapidly increase with respect to stretch. This method of calculating compliance as stress vs stretch also showed that the mechanical properties of the bladder wall remain similar in bladders of varying capacity. This study demonstrates how wall tension, stress and stretch can be measured, quantified, and used to accurately define bladder wall biomechanics in terms of actual material properties and not pressure/volume changes. This method is especially useful for determining how changes in bladder biomechanics are altered in pathologies where profound bladder wall remodeling occurs, such as diabetes and spinal cord injury. The online version contains supplementary material available at 10.1007/s10237-023-01727-0.
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影响因子：
1.6
作者：
Maddra, Kaitlyn M.;Li, Rui;Nagle, Anna S.;Klausner, Adam P.;Speich, John E.
通讯作者：
Speich, John E.
影响因子：
9.7
作者：
Tuttle TG;Lujan HL;Tykocki NR;DiCarlo SE;Roccabianca S
通讯作者：
Roccabianca S
影响因子：
2.4
作者：
Nagle, Anna S.;Klausner, Adam P.;Speich, John E.
通讯作者：
Speich, John E.
影响因子：
9.7
作者：
Zwaans, Bernadette M. M.;Grobbel, Marissa;Carabulea, Alexander L.;Lamb, Laura E.;Roccabianca, Sara
通讯作者：
Roccabianca, Sara
影响因子：
6.6
作者：
Gloeckner, DC;Sacks, MS;Chancellor, MB
通讯作者：
Chancellor, MB