Drosophila Neuropeptide F Signaling Independently Regulates Feeding and Sleep-Wake Behavior.
Drosophila Neuropeptide F Signaling Independently Regulates Feeding and Sleep-Wake Behavior.
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DOI：
10.1016/j.celrep.2017.05.085
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发表时间：
2017-06-20
期刊：
影响因子：
8.8
通讯作者：
Pletcher SD
中科院分区：
文献类型：
--
作者：
Chung BY;Ro J;Hutter SA;Miller KM;Guduguntla LS;Kondo S;Pletcher SD
适当地调节睡眠-觉醒行为和进食对生物体的健康和生存至关重要。虽然之前的研究已经分离出对睡眠或进食至关重要的离散神经位点和底物，但大脑是如何组织起来相互协调这两个过程的仍然知之甚少。在这里，我们提供了证据表明，果蝇神经肽F(NPF)网络形成了成年睡眠和摄食调节的关键组成部分。大脑中NPF信号的激活可能通过其同源受体NPFR促进觉醒和成人进食。携带功能丧失的NPF等位基因的苍蝇在长期饥饿条件下不会抑制睡眠，这表明NPF充当饥饿信号，让动物保持清醒。表达NPF的细胞，特别是那些表达昼夜节律光感受器隐色素的细胞，主要负责NPF神经元激活而不是摄食引起的睡眠行为的改变，这表明不同的NPF神经元分别驱动觉醒和饥饿。为了最佳的健康，睡眠和进食行为必须相互协调，不能相互冲突。然而，目前还不清楚大脑是如何做到这一点的。Chung等人证明增强的神经肽F(NPF)信号促进觉醒和摄食行为，可能是通过表达NPF的神经元的不同亚群。
Proper regulation of sleep-wake behavior and feeding is essential for organismal health and survival. While previous studies have isolated discrete neural loci and substrates important for either sleep or feeding, how the brain is organized to coordinate both processes with respect to one another remains poorly understood. Here, we provide evidence that the Drosophila Neuropeptide F (NPF) network forms a critical component of both adult sleep and feeding regulation. Activation of NPF signaling in the brain promotes wakefulness and adult feeding, likely through its cognate receptor NPFR. Flies carrying a loss-of-function NPF allele do not suppress sleep following prolonged starvation conditions, suggesting that NPF acts as a hunger signal to keep the animal awake. NPF-expressing cells, specifically those expressing the circadian photoreceptor cryptochrome, are largely responsible for changes to sleep behavior caused by NPF neuron activation, but not feeding, demonstrating that different NPF neurons separately drive wakefulness and hunger. For optimal health, sleep and feeding behavior must be coordinated to not conflict with one another. However, it is unclear how the brain accomplishes this. Chung et al. demonstrate that enhanced Neuropeptide F (NPF) signaling promotes wakefulness and feeding behavior, presumably through different subsets of NPF-expressing neurons.
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DOI：
10.1073/pnas.0702726104
发表时间：
2007-05-15
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
9.2
作者：
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影响因子：
4.5
作者：
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通讯作者：
Wegener C
影响因子：
5.6
作者：
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通讯作者：
Zhao, Zhangwu
影响因子：
2.5
作者：
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通讯作者：
Helfrich-Foerster, Charlotte