Quantitative detection of Merkel cell virus in human tissues and possible mode of transmission.
Quantitative detection of Merkel cell virus in human tissues and possible mode of transmission.
复制标题
DOI：
10.1002/ijc.24737
复制
发表时间：
2010-06-15
影响因子：
6.4
通讯作者：
Sidransky, David
中科院分区：
文献类型：
--
作者：
Loyo, Myriam;Guerrero-Preston, Rafael;Brait, Mariana;Hoque, Mohmammad O.;Chuang, Alice;Kim, Myoung S.;Sharma, Rajni;Liegeois, Nanette J.;Koch, Wayne M.;Califano, Joseph A.;Westra, William H.;Sidransky, David
默克尔细胞病毒（MCV）是最近在一种罕见的皮肤癌默克尔细胞癌中发现的一种新发现的多瘤病毒。然而，在一些正常组织样品中也检测到MCV。我们测试并比较了一组不同人体组织样本中MCV的相对数量与默克尔细胞癌样本。默克尔细胞癌中MCV的水平比所有其他组织中的最高值高60倍以上。在不同的组织样本中检测到少量的MCV，与恶性或良性组织学状态无关。与肺和泌尿生殖系统样本相比，在上呼吸消化道、消化系统和唾液中发现了更高水平的病毒。这些结果证实MCV在人体内广泛存在，并提示可能存在类似于甲型肝炎病毒的粪-口传播途径。尽管病毒广泛存在，但似乎只有神经内分泌皮肤细胞对MCV的转化敏感。
Merkel Cell Virus (MCV) is a newly discovered polyoma virus recently found in a rare skin cancer, Merkel cell carcinoma. However, MCV has also been detected in some normal tissue samples. We tested and compared the relative quantity of the MCV in a set of diverse human tissue samples with the Merkel cell carcinoma samples. The levels of MCV in Merkel cell carcinomas were over 60 times higher than the highest values in all other tissues. Low quantities of MCV were detected in diverse tissue samples independently of malignant or benign histologic status. Higher levels of the virus were found in the upper aerodigestive tract, digestive system, and saliva compared to the lung and genitourinary system samples. These results confirm that MCV is widespread in the human body and suggest a possible fecal-oral transmission route similar to the Hepatitis A virus. Despite widespread presence of the virus, it appears that only neuroendocrine skin cells are susceptible to transformation by MCV.
登录
查看更多内容
影响因子：
12.7
作者：
BRADE, L;MULLERLANTZSCH, N;HAUSEN, HZ
通讯作者：
HAUSEN, HZ
影响因子：
8.8
作者：
Newton, R;Ribeiro, T;Coursaget, P
通讯作者：
Coursaget, P
影响因子：
168.9
作者：
Engels, EA;Frisch, M;Miller, RW
通讯作者：
Miller, RW
影响因子：
5.4
作者：
Allander, Tobias;Andreasson, Kalle;Andersson, Bjorn
通讯作者：
Andersson, Bjorn
影响因子：
7.5
作者：
Duncavage, Eric J.;Zehnbauer, Barbara A.;Pfeifer, John D.
通讯作者：
Pfeifer, John D.