Animal foods, protein, calcium and prostate cancer risk: the European Prospective Investigation into Cancer and Nutrition.
Animal foods, protein, calcium and prostate cancer risk: the European Prospective Investigation into Cancer and Nutrition.
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DOI：
10.1038/sj.bjc.6604331
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发表时间：
2008-05-06
影响因子：
8.8
通讯作者：
Riboli, E.
中科院分区：
文献类型：
--
作者：
Allen, N. E.;Key, T. J.;Appleby, P. N.;Travis, R. C.;Roddam, A. W.;Tjonneland, A.;Johnsen, N. F.;Overvad, K.;Linseisen, J.;Rohrmann, S.;Boeing, H.;Pischon, T.;Bueno-de-Mesquita, H. B.;Kiemeney, L.;Tagliabue, G.;Palli, D.;Vineis, P.;Tumino, R.;Trichopoulou, A.;Kassapa, C.;Trichopoulos, D.;Ardanaz, E.;Larranaga, N.;Tormo, M-J;Gonzalez, C. A.;Quiros, J. R.;Sanchez, M-J;Bingham, S.;Khaw, K-T;Manjer, J.;Berglund, G.;Stattin, P.;Hallmans, G.;Slimani, N.;Ferrari, P.;Rinaldi, S.;Riboli, E.
在欧洲癌症和营养前瞻性调查中，我们调查了142名 251名男性中动物性食物、蛋白质和钙的摄入量与前列腺癌风险的关系。用考克斯回归检验相关因素，按招募中心分层，并根据身高、体重、教育程度、婚姻状况和能量摄入进行调整。经过平均8.7年的随访，共有2727例前列腺癌病例，其中1131例已知为局限性前列腺癌，541例为晚期前列腺癌。乳制品蛋白质摄入量高与风险增加相关，乳制品蛋白质摄入量最高的五分之一与摄入量最低的五分之一的风险比为1.22(95%可信区间：1.07-1.41，P趋势=0.02)。在考虑到测量误差的校正后，我们估计，乳制品蛋白摄入量增加35克 天−1与前列腺癌风险增加32%相关(95%可信区间：1-72%，P趋势=0.04)。来自乳制品的钙也与风险呈正相关，但来自其他食物的钙与风险无关。这些结果支持了这样的假设，即从乳制品中摄取大量蛋白质或钙可能会增加患前列腺癌的风险。
We examined consumption of animal foods, protein and calcium in relation to risk of prostate cancer among 142 251 men in the European Prospective Investigation into Cancer and Nutrition. Associations were examined using Cox regression, stratified by recruitment centre and adjusted for height, weight, education, marital status and energy intake. After an average of 8.7 years of follow-up, there were 2727 incident cases of prostate cancer, of which 1131 were known to be localised and 541 advanced-stage disease. A high intake of dairy protein was associated with an increased risk, with a hazard ratio for the top versus the bottom fifth of intake of 1.22 (95% confidence interval (CI): 1.07–1.41, Ptrend=0.02). After calibration to allow for measurement error, we estimated that a 35-g day−1 increase in consumption of dairy protein was associated with an increase in the risk of prostate cancer of 32% (95% CI: 1–72%, Ptrend=0.04). Calcium from dairy products was also positively associated with risk, but not calcium from other foods. The results support the hypothesis that a high intake of protein or calcium from dairy products may increase the risk for prostate cancer.
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影响因子：
3.8
作者：
Ahn, Jiyoung;Albanes, Demetrius;Hayes, Richard B.
通讯作者：
Hayes, Richard B.
影响因子：
9.8
作者：
CLEMMONS, DR;SEEK, MM;UNDERWOOD, LE
通讯作者：
UNDERWOOD, LE
影响因子：
6.4
作者：
Ganmaa, D;Li, XM;Sato, A
通讯作者：
Sato, A
DOI：
10.1016/s0002-8223(99)00302-8
发表时间：
1999-10-01
影响因子：
--
作者：
Heaney, RP;McCarron, DA;Rosen, CJ
通讯作者：
Rosen, CJ
影响因子：
3.2
作者：
Ferrari, P;Slimani, N;Riboli, E
通讯作者：
Riboli, E