The Dose-Response Effects of Consuming High Fructose Corn Syrup-Sweetened Beverages on Hepatic Lipid Content and Insulin Sensitivity in Young Adults.
The Dose-Response Effects of Consuming High Fructose Corn Syrup-Sweetened Beverages on Hepatic Lipid Content and Insulin Sensitivity in Young Adults.
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作者：
肝脏脂质含量增加和胰岛素敏感性降低在心脏代谢疾病的发展中起着关键作用。因此，我们的目的是研究食用高果糖玉米糖浆（HFCS）加糖饮料两周对年轻（18-40岁）成人（BMI 18-35 kg/m2）肝脏脂质含量和胰岛素敏感性的剂量反应效应。在一项平行的双盲研究中，参与者每天饮用三种饮料，每天提供0%（西莫司：n = 23），10%（n = 18），17.5%（n = 16）或25%（n = 28）的HFCS每日能量需求。在基线和15天干预结束时，在3.5天住院访视期间进行肝脏脂质含量和口服葡萄糖耐量试验（OGTT）的磁共振成像。在12个干预门诊日期间，参与者消耗了他们的日常饮食和分配的饮料。在OGTT期间观察到肝脏脂质含量（p = 0.015）和葡萄糖和胰岛素AUC（均p = 0.0004）增加以及胰岛素敏感性的Matsuda（p = 0.0087）和预测M（p = 0.0027）指数降低的显著线性剂量反应效应。这些剂量-反应效应强化了机制证据，表明含氢氟碳化合物甜味饮料的消费是导致代谢失调的一个因素，而代谢失调会增加非酒精性脂肪肝和2型糖尿病的风险。
Increased hepatic lipid content and decreased insulin sensitivity have critical roles in the development of cardiometabolic diseases. Therefore, our objective was to investigate the dose-response effects of consuming high fructose corn syrup (HFCS)-sweetened beverages for two weeks on hepatic lipid content and insulin sensitivity in young (18–40 years) adults (BMI 18–35 kg/m2). In a parallel, double-blinded study, participants consumed three beverages/day providing 0% (aspartame: n = 23), 10% (n = 18), 17.5% (n = 16), or 25% (n = 28) daily energy requirements from HFCS. Magnetic resonance imaging for hepatic lipid content and oral glucose tolerance tests (OGTT) were conducted during 3.5-day inpatient visits at baseline and again at the end of a 15-day intervention. During the 12 intervening outpatient days participants consumed their usual diets with their assigned beverages. Significant linear dose-response effects were observed for increases of hepatic lipid content (p = 0.015) and glucose and insulin AUCs during OGTT (both p = 0.0004), and for decreases in the Matsuda (p = 0.0087) and Predicted M (p = 0.0027) indices of insulin sensitivity. These dose-response effects strengthen the mechanistic evidence implicating consumption of HFCS-sweetened beverages as a contributor to the metabolic dysregulation that increases risk for nonalcoholic fatty liver disease and type 2 diabetes.
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影响因子：
4.2
作者：
Caussy C;Aubin A;Loomba R
通讯作者：
Loomba R
影响因子：
6.7
作者：
Ciardullo, Stefano;Perseghin, Gianluca
通讯作者：
Perseghin, Gianluca
DOI：
10.1002/hep.29797
发表时间：
2018-08
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Caussy C;Reeder SB;Sirlin CB;Loomba R
通讯作者：
Loomba R
影响因子：
4.8
作者：
Han, Euna;Powell, Lisa M.
通讯作者：
Powell, Lisa M.
人类脂肪肝病：旧问题和新见解。
DOI：
10.1126/science.1204265
发表时间：
2011-06-24
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Cohen JC;Horton JD;Hobbs HH
通讯作者：
Hobbs HH