Enhancing the effects of chemotherapy by combined macrophage-mediated photothermal therapy (PTT) and photochemical internalization (PCI).
Enhancing the effects of chemotherapy by combined macrophage-mediated photothermal therapy (PTT) and photochemical internalization (PCI).
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DOI：
10.1007/s10103-018-2534-5
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发表时间：
2018-11
影响因子：
2.1
通讯作者：
Hirschberg H
中科院分区：
文献类型：
--
作者：
Nair RK;Christie C;Ju D;Shin D;Pomeroy A;Berg K;Peng Q;Hirschberg H
光热疗法（PTT）或光化学内化（PCI）等基于光的治疗方式在实验和临床中都有很好的记录，可以提高化疗的疗效。本研究的主要目的是研究二氧化硅-金纳米壳（AuNS）负载巨噬细胞介导（MaNS） PTT和博来霉素BLMPCI对鳞状细胞单层癌细胞的细胞毒性作用。这两种方式分别应用，同时结合应用。同时使用两种不同波长的光，一种用于激活高效的PCI光敏剂AlPcS2a (670 nm)，另一种用于激活mans介导的PTT (810 nm)，以评估这些方式的综合效果。结果清楚地表明，巨噬细胞可以摄取足够数量的硅金纳米壳，用于有效的近红外（NIR）激活PTT。与单独应用PTT和PCI相比，同时应用PTT和PCI具有显著的协同效应。光驱动疗法具有部位特异性，非侵入性和无毒应用，需要廉价的设备，可以作为重复治疗方案。
Light-based treatment modalities such as photothermal therapy (PTT) or photochemical internalization (PCI) have been well documented both experimentally and clinically to enhance the efficacy of chemotherapy. The main purpose of this study was to examine the cytotoxic effects of silica–gold nanoshell (AuNS)-loaded macrophage-mediated (MaNS) PTT and bleomycin BLMPCI on monolayers of squamous cell carcinoma cells. The two modalities were applied separately and in simultaneous combination. Two different wavelengths of lig7ht were employed simultaneously, one to activate a highly efficient PCI photosensitizer,AlPcS2a (670 nm) and the other for the MaNS-mediated PTT (810 nm), to evaluate the combined effects of these modalities. The results clearly demonstrated that macrophages could ingest sufficient numbers of silica–gold nanoshells for efficient near infrared (NIR) activated PTT. A significant synergistic effect of simultaneously applied combined PTT and PCI, compared to each modality applied separately, was achieved. Light-driven therapies have the advantage of site specificity, non-invasive and nontoxic application, require inexpensive equipment and can be given as repetitive treatment protocols.
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影响因子：
2.4
作者：
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通讯作者：
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影响因子：
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作者：
Oldenburg, SJ;Jackson, JB;Halas, NJ
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作者：
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DOI：
10.1016/j.ijrobp.2009.04.039
发表时间：
2009-11-01
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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