Response to the dipeptidyl peptidase-4 inhibitors in Japanese patients with type 2 diabetes might be associated with a diplotype of two single nucleotide polymorphisms on the interleukin-6 promoter region under a certain level of physical activity.
Response to the dipeptidyl peptidase-4 inhibitors in Japanese patients with type 2 diabetes might be associated with a diplotype of two single nucleotide polymorphisms on the interleukin-6 promoter region under a certain level of physical activity.
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DOI：
10.1111/jdi.12260
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发表时间：
2015-03
影响因子：
3.2
通讯作者：
Satoh J
中科院分区：
文献类型：
--
作者：
Matsui M;Takahashi Y;Takebe N;Takahashi K;Nagasawa K;Honma H;Oda T;Ono M;Nakagawa R;Sasai T;Togashi H;Hangai M;Kajiwara T;Taneichi H;Ishigaki Y;Satoh J
据报道，肌源性白细胞介素-6（IL-6）可促进胰高血糖素样肽-1（GLP-1）分泌，我们探讨了人IL-6启动子区单核苷酸多态性（SNP）与二肽基肽酶-4抑制剂（DPP-4 Is）（增加循环GLP-1的药物）反应性的相关性。本观察性研究入组了服用DPP-4 I超过3个月的日本2型糖尿病患者，并回顾性收集了大部分临床信息。我们将无应答者定义为开始DPP-4 I治疗后3或4个月糖化血红蛋白水平下降<0.2%的患者。体力活动采用日本版国际体力活动问卷进行回顾性评估。我们研究了316名患者，估计了与DPP-4 I给药季节对应的身体活动。无应答率为29.7%。我们分析了rs 1800796和rs 2097677，两者都被认为在日语中是功能性的。对所有患者的多因素分析显示，双体型rs 1800796 G/*-rs 2097677 A/* 与C/C-G/G相比，无应答风险的校正比值比（OR_G*A*）为0.445（P = 0.068）。按国际体力活动问卷分为低活动组（n = 149）和中/高活动组（n = 167），OR_G*A* 分别为1.58（P = 0.615）和0.153（P = 0.003）。在日本2型糖尿病患者中，rs 1800796 G/*-rs 2097677 A/* 可能有助于在一定水平的体力活动下对DPP-4 Is的反应。然而，需要进一步调查以证实这一点。
Muscle-derived interleukin-6 (IL-6) has been reported to promote glucagon-like peptide-1 (GLP-1) secretion, and we explored the association of single nucleotide polymorphisms (SNPs) in the human IL-6 promoter region with the responsiveness to dipeptidyl peptidase-4 inhibitors (DPP-4Is), drugs that increase circulating GLP-1. The present observational study enrolled Japanese patients with type 2 diabetes who took a DPP-4I over 3 months, and most of the clinical information was collected retrospectively. We defined non-responders as those having less than a 0.2% decrease of the glycated hemoglobin level at 3 or 4 months after starting DPP-4I treatment. Physical activity was retrospectively estimated by the Japanese short version of International Physical Activity Questionnaire. We studied 316 patients whose physical activity corresponding to the season of the DPP-4I administration was estimated. The non-responder rate was 29.7%. We analyzed rs1800796 and rs2097677, both are suggested to be functional in Japanese. Multivariate analysis for all patients showed that the adjusted odds ratio for the non-responder risk of the diplotype rs1800796 G/*–rs2097677 A/* against C/C-G/G (OR_G*A*) was 0.445 (P = 0.068). When patients were stratified by the International Physical Activity Questionnaire into low (n = 149) and moderate/high (n = 167) activity groups, however, OR_G*A* in each group was 1.58 (P = 0.615) and 0.153 (P = 0.003), respectively. The diplotype rs1800796 G/*–rs2097677 A/* might contribute to responsiveness to DPP-4Is in Japanese patients with type 2 diabetes under a certain level of physical activity. However, further investigation is warranted to confirm this.
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影响因子：
16.2
作者：
Fröhlich, M;Imhof, A;Koenig, W
通讯作者：
Koenig, W
DOI：
10.1111/j.1600-0838.2006.00602.x
发表时间：
2007-10-01
影响因子：
4.1
作者：
Fischer, C. P.;Berntsen, A.;Pedersen, B. K.
通讯作者：
Pedersen, B. K.
影响因子：
5.8
作者：
Lee, Sang Ah;Kim, Young Ree;Lee, Dae Ho
通讯作者：
Lee, Dae Ho
影响因子：
7.7
作者：
Jiang LQ;Duque-Guimaraes DE;Machado UF;Zierath JR;Krook A
通讯作者：
Krook A
影响因子：
2.6
作者：
Excoffier, Laurent;Laval, Guillaume;Schneider, Stefan
通讯作者：
Schneider, Stefan