Multiple metal exposures and metabolic syndrome: A cross-sectional analysis of the National Health and Nutrition Examination Survey 2011-2014.
Multiple metal exposures and metabolic syndrome: A cross-sectional analysis of the National Health and Nutrition Examination Survey 2011-2014.
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DOI：
10.1016/j.envres.2018.10.022
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发表时间：
2019-01
影响因子：
8.3
通讯作者：
Argos M
中科院分区：
文献类型：
--
作者：
Bulka CM;Persky VW;Daviglus ML;Durazo-Arvizu RA;Argos M
流行病学研究表明，有毒金属与糖尿病和心血管疾病有关，而实验研究表明，营养必需金属参与了大量营养素的代谢和对氧化应激的防御。我们试图评估必需和有毒金属如何与代谢综合征（一组心脏代谢疾病）相关。使用2011-2014年国家健康和营养检查调查（n= 1，088）的数据，我们描述了现场尿液（砷，镉和无机/元素汞），全血（锰，铅，甲基汞和硒）和血清（铜和锌）样本中测量的金属浓度。进行了主成分分析，以得出暴露模式。根据2009年联合科学声明，代谢综合征定义为存在≥3种以下疾病：高血压、高甘油三酯、低HDL胆固醇、高空腹血糖和腹部肥胖。校正潜在混杂因素后，代谢综合征的患病率最高与最低四分位数比较为1.41（95%置信区间：1.18-1.67）砷-无机/元素汞模式，0.95（0.78-1.16）甲基汞-锰模式，73（0.57-0.94），铜图案为0.91（0.76-1.10），硒锌图案为1.36（1.13-1.63）。砷-无机汞/元素汞模式中观察到的正相关性是由于高血压、低HDL胆固醇和高甘油三酯在接触较多的人群中的患病率升高。硒-锌模式的关联是由与高甘油三酯的正相关关系驱动的。更大的铅镉共同暴露与血脂异常和腹部肥胖的患病率较低。这些横断面研究结果表明，有毒和必需金属暴露可能有助于心脏代谢健康，但需要用前瞻性数据证实。
Epidemiologic studies suggest toxic metals are linked with diabetes and cardiovascular disease, while experimental studies indicate nutritionally essential metals are involved in the metabolism of macronutrients and defense against oxidative stress. We sought to evaluate how essential and toxic metals are cross-sectionally related to metabolic syndrome, a clustering of cardiometabolic conditions. Using data from the 2011-2014 National Health and Nutrition Examination Survey (n=1,088), we characterized metal concentrations as measured in spot urine (arsenic, cadmium, and inorganic/elemental mercury), whole blood (manganese, lead, methylmercury, and selenium), and serum (copper and zinc) samples. Principal component analysis was performed to derive patterns of exposures. Metabolic syndrome was defined according to the 2009 Joint Scientific Statement as the presence of ≥3 of the following conditions: high blood pressure, high triglycerides, low HDL cholesterol, high fasting glucose, and abdominal obesity. After adjustment for potential confounders, prevalence ratios for metabolic syndrome comparing the highest to the lowest quartiles were 1.41 (95% CI: 1.18-1.67) for the arsenic-inorganic/elemental mercury pattern, 0.95 (0.78-1.16) for the methylmercury-manganese pattern, 73 (0.57-0.94) for the cadmium-lead pattern, 0.91 (0.76-1.10) for the copper pattern, and 1.36 (1.13-1.63) for the selenium-zinc pattern. The positive associations observed for the arsenic-inorganic/elemental mercury pattern were due to an elevated prevalence of high blood pressure, low HDL cholesterol, and high triglycerides among those with greater exposures. Associations for the selenium-zinc pattern were driven by a positive relationship with high triglycerides. Greater lead-cadmium co-exposures were related to a lower prevalence of dyslipidemia and abdominal obesity. These cross-sectional findings suggest both toxic and essential metal exposures may contribute to cardiometabolic health, but need to be confirmed with prospective data.
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DOI：
10.1016/j.scitotenv.2015.07.024
发表时间：
2015-12-01
期刊：
The Science of the total environment
影响因子：
--
作者：
Dickerson AS;Rahbar MH;Han I;Bakian AV;Bilder DA;Harrington RA;Pettygrove S;Durkin M;Kirby RS;Wingate MS;Tian LH;Zahorodny WM;Pearson DA;Moyé LA 3rd;Baio J
通讯作者：
Baio J
砷和肥胖症：尿液稀释调节方法的比较。
影响因子：
10.4
作者：
Bulka CM;Mabila SL;Lash JP;Turyk ME;Argos M
通讯作者：
Argos M
影响因子：
37.8
作者：
Alberti, K. G. M. M.;Eckel, Robert H.;Smith, Sidney C., Jr.
通讯作者：
Smith, Sidney C., Jr.
影响因子：
10.4
作者：
Hays SM;Aylward LL;Blount BC
通讯作者：
Blount BC
影响因子：
10.4
作者：
Han, SG;Li, WJ;Bogden, JD
通讯作者：
Bogden, JD