Sequence of changes in rat buccal mucosa induced by zinc deficiency.

Sequence of changes in rat buccal mucosa induced by zinc deficiency.
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缺锌引起的大鼠颊粘膜的变化序列。

DOI:
10.1111/j.1600-0714.1991.tb00436.x
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发表时间:
1991
期刊:
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
影响因子:
--
通讯作者:
Daniel,J
Daniel,J
中科院分区:
--
文献类型:
--
作者:
Hsu,D;Meyer,J;Gerson,S;Daniel,J

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在断奶大鼠中,接受缺锌饮食(<1 ppm)4周后,颊粘膜出现增生。这项研究确定了病变早期的变化。9天后的缺乏,角蛋白层已部分转化为角化不全和增厚,毛细血管床的大小增加。18天后,角蛋白层完全角化不全并进一步增厚。细胞层增厚。有丝分裂率加倍,率脊卷曲。27天后,角蛋白和细胞层进一步增厚,有丝分裂率仍保持较高水平。利率脊进一步弯曲。肥大细胞的数量增加了一倍,血管床的大小进一步增加。这些发现表明上皮和固有层之间的早期和晚期相互作用。缺锌27天后,对照饮食4天后,粘膜恢复正常。
In weanling rats, after receiving a zinc‐deficient diet (<1 ppm) for 4 wk, the buccal mucosa appears hyperplastic. This study determines changes at earlier stages of the lesion. After 9 days of deficiency, the keratin layer had partially converted to parakeratosis and thickened, and the size of the capillary bed was increased. After 18 days, the keratin layer was fully parakeratotic and thickened further. The cellular layer was thickened. The mitotic rate was doubled and rate ridges were convoluted. After 27 days, the keratin and cellular layers were further thickened, and the mitotic rate remained elevated. The rate ridges were further convoluted. The number of mast cells was doubled and the size of the vascular bed had increased further. These findings suggest early and late interactions between the epithelium and lamina propria. After four days on a control diet following 27 days of zinc deficiency, the mucosa returned normal.
DOI: 10.1111/1523-1747.ep13077211
发表时间: 1972
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影响因子: --
作者:
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影响因子: --
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