Molecular analysis of household transmission of Giardia lamblia in a region of high endemicity in Peru.
Molecular analysis of household transmission of Giardia lamblia in a region of high endemicity in Peru.
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DOI：
10.1086/657142
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发表时间：
2010-12-01
期刊：
影响因子：
--
通讯作者：
Adam RD
中科院分区：
文献类型：
--
作者：
Cooper MA;Sterling CR;Gilman RH;Cama V;Ortega Y;Adam RD
蓝氏贾第鞭毛虫在非工业化国家的多个社区中普遍存在。基因型 A1、A2 和 B（分别为纳什族 1、2 和 3）见于人类，而基因型 C 和 D 通常见于狗。然而，偶尔在狗身上发现了基因型 A 和 B。 2002 年在圣胡安潘帕斯地区的 22 个家庭及其狗中收集了粪便贾第鞭毛虫分离株，分别于 2002 年 7 周和 2003 年 6 周内收集。对样本进行了基因分型，然后使用 3 号和 5 号染色体上的位点对其中许多分离株进行了测序和单倍型分析。人类感染均由基因型 A2 和 B 的分离株引起。人类同时感染基因型 A2 和 B 很常见， A2 分离株不同亚型的重配模式支持了先前的观察结果，表明基因型 A2 分离株之间存在重组。所有狗都具有 C 和/或 D 基因型，只有一只狗具有混合 B/D 基因型感染。在受感染的狗和人类不断混合的高度流行地区，不同基因型的贾第鞭毛虫几乎总是在狗和人类身上发现，这表明人畜共患传播非常罕见。
Giardia lamblia is ubiquitous in multiple communities of non-industrialized nations. Genotypes A1, A2, and B (Nash groups 1, 2, and 3, respectively) are found in humans, while genotypes C and D are typically found in dogs. However Genotypes A and B have occasionally been identified in dogs. Fecal Giardia isolates from 22 families and their dogs, living in Pampas de San Juan, were collected over seven weeks in 2002 and six weeks in 2003. Samples were genotyped, followed by sequencing and haplotyping of many of these isolates, using loci on chromosomes 3 and 5. Human infections were all caused by isolates of genotypes A2 and B. Human co-infections with Genotypes A2 and B were common, and the reassortment pattern of different subtypes of A2 isolates supports prior observations suggesting recombination among Genotype A2 isolates. All dogs had genotypes C and/or D with one exception of a dog with a mixed B/D genotype infection. In a highly endemic region where infected dogs and humans constantly commingle, different genotypes of Giardia are almost always found in dogs and humans, suggesting that zoonotic transmission is very uncommon.
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影响因子：
11.8
作者：
Bern C;Ortega Y;Checkley W;Roberts JM;Lescano AG;Cabrera L;Verastegui M;Black RE;Sterling C;Gilman RH
通讯作者：
Gilman RH
影响因子：
2.6
作者：
Berrilli, F;Di Cave, D;Orecchia, P
通讯作者：
Orecchia, P
影响因子：
2.4
作者：
Traub, RJ;Monis, PT;Thompson, RCA
通讯作者：
Thompson, RCA
影响因子：
9.2
作者：
Cooper, Margarethe A.;Adam, Rodney D.;Sterling, Charles R.
通讯作者：
Sterling, Charles R.
影响因子：
168.9
作者：
GILMAN, RH;MIRANDA, E;MARTINEZ, H
通讯作者：
MARTINEZ, H