Celiac disease symptom profiles and their relationship to gluten-free diet adherence, mental health, and quality of life.
Celiac disease symptom profiles and their relationship to gluten-free diet adherence, mental health, and quality of life.
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DOI：
10.1186/s12876-023-03101-x
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发表时间：
2024-01-02
影响因子：
2.4
通讯作者：
Mcbeth, Julia F.
中科院分区：
文献类型：
--
作者：
Dochat, Cara;Afari, Niloofar;Satherley, Rose-Marie;Coburn, Shayna;Mcbeth, Julia F.
患有乳糜泻的成人亚群会出现持续的胃肠道和肠外症状，这些症状因人而异，而且其原因往往不清楚。本观察性研究旨在阐明成人乳糜泻在线样本中持续症状的模式以及这些模式与无麸质饮食依从性、精神症状和生活质量 (QOL) 各个方面之间的关系。作为 iCureCeliac® 研究网络的一部分，自我报告的、经活检确诊的乳糜泻的美国成年人（N = 523；Mage = 40.3 岁；88% 女性；93.5% 白人）自愿填写问卷，作为 iCureCeliac® 研究网络的一部分：(a) 针对身体症状和主观健康状况的乳糜泻症状指数 (CSI)； (b) 针对无麸质饮食依从性的乳糜泻饮食依从性测试； (c) PROMIS-29、SF-36 和乳糜泻精神症状和 QOL 生活质量调查。使用潜在特征分析得出症状特征，并使用辅助分析检查特征差异。 CSI 项目的潜在配置文件分析确定了最适合的四配置文件解决方案。概况的特点是：(1) 几乎没有症状，主观健康状况良好（样本的 37%）； （2）症状少见，主观健康状况良好（33%）； (3) 偶有症状且主观健康状况一般至较差（24%）； (4) 症状频繁至持续，主观健康状况一般至较差（6%）。概况 2 和概况 3 报告总体症状中等，但概况 2 报告相对较严重的肠外症状，概况 3 报告相对较重的胃肠道症状、身体疼痛和较差的主观健康状况。焦虑和抑郁症状、身体和情绪健康限制、社交功能和睡眠方面存在差异，但临床特征、无麸质饮食依从性或生活质量方面没有差异。尽管根据 CSI 的报告，概况 3 的症状负担中等且主观健康状况较低，但根据标准化测量，概况 3 报告的精神症状最低，生活质量最高。患有乳糜泻的成年人报告了不同的持续症状、症状严重程度和主观健康状况。无麸质饮食依从性方面缺乏差异表明辅助饮食或医疗评估和干预可能是必要的。较低的持续症状负担并不一定意味着更好的心理健康和生活质量，这表明行为干预即使对于那些乳糜泻症状负担较低的人也可能有帮助。在线版本包含可在 10.1186/s12876-023-03101-x 获取的补充材料。
A subgroup of adults with celiac disease experience persistent gastrointestinal and extraintestinal symptoms, which vary between individuals and the cause(s) for which are often unclear. The present observational study sought to elucidate patterns of persistent symptoms and the relationship between those patterns and gluten-free diet adherence, psychiatric symptoms, and various aspects of quality of life (QOL) in an online sample of adults with celiac disease. U.S. adults with self-reported, biopsy-confirmed celiac disease (N = 523; Mage = 40.3 years; 88% women; 93.5% White) voluntarily completed questionnaires as part of the iCureCeliac® research network: (a) Celiac Symptoms Index (CSI) for physical symptoms and subjective health; (b) Celiac Dietary Adherence Test for gluten-free diet adherence; (c) PROMIS-29, SF-36, and Celiac Disease Quality of Life Survey for psychiatric symptoms and QOL. Symptom profiles were derived using latent profile analysis and profile differences were examined using auxiliary analyses. Latent profile analysis of CSI items determined a four-profile solution fit best. Profiles were characterized by: (1) little to no symptoms and excellent subjective health (37% of sample); (2) infrequent symptoms and good subjective health (33%); (3) occasional symptoms and fair to poor subjective health (24%); (4) frequent to constant symptoms and fair to poor subjective health (6%). Profiles 2 and 3 reported moderate overall symptomology though Profile 2 reported relatively greater extraintestinal symptoms and Profile 3 reported relatively greater gastrointestinal symptoms, physical pain, and worse subjective health. Profiles differed on anxiety and depression symptoms, limitations due to physical and emotional health, social functioning, and sleep, but not clinical characteristics, gluten-free diet adherence, or QOL. Despite Profile 3’s moderate symptom burden and low subjective health as reported on the CSI, Profile 3 reported the lowest psychiatric symptoms and highest quality of life on standardized measures. Adults with celiac disease reported variable patterns of persistent symptoms, symptom severity, and subjective health. Lack of profile differences in gluten-free diet adherence suggests that adjunctive dietary or medical assessment and intervention may be warranted. Lower persistent symptom burden did not necessarily translate to better mental health and QOL, suggesting that behavioral intervention may be helpful even for those with lower celiac symptom burden. The online version contains supplementary material available at 10.1186/s12876-023-03101-x.
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影响因子：
3.9
作者：
Durazzo M;Ferro A;Brascugli I;Mattivi S;Fagoonee S;Pellicano R
通讯作者：
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通讯作者：
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