Extra-Intestinal Manifestations of Celiac Disease: What Should We Know in 2022?
Extra-Intestinal Manifestations of Celiac Disease: What Should We Know in 2022?
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DOI：
10.3390/jcm11010258
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发表时间：
2022-01-04
影响因子：
3.9
通讯作者：
Pellicano R
中科院分区：
文献类型：
--
作者：
Durazzo M;Ferro A;Brascugli I;Mattivi S;Fagoonee S;Pellicano R
乳糜泻（CD）是一种慢性，小肠，免疫介导的肠病，由于面筋暴露在遗传易感个体。它发生在大约1%的人口中，并且通常仍然是一种诊断不足的疾病。这可能是由于成年人群通常缺乏CD的经典体征和症状，仅表现出非典型症状。在这篇综述中，我们分析了CD的主要肠外表现，包括皮肤和内分泌疾病，肝功能检查异常和神经精神病学特征。当CD没有被诊断出来，因此没有用无麸质饮食（GFD）治疗时，它可能容易发生严重的并发症，而不仅仅是胃肠道并发症。因此，考虑到早期诊断可显著影响患者的预后，临床医生快速识别CD的非典型表现非常重要。
Celiac disease (CD) is a chronic, small-intestinal, immune-mediated enteropathy due to gluten exposition in genetically predisposed individuals. It occurs in about 1% of the population and often remains an underdiagnosed condition. This could be due to the fact that the adult population often lacks the classical signs and symptoms of CD, manifesting only atypical symptoms. In this review we analyzed the main extra-intestinal manifestations of CD which include cutaneous and endocrinological disorders, abnormal liver function tests, and neuropsychiatric features. When CD is not diagnosed and therefore is not treated with a gluten-free diet (GFD), it can predispose to severe complications, not only gastrointestinal. Thus, it is important for clinicians to quickly recognize the atypical manifestations of CD, considering that an early diagnosis can significantly impact on a patient’s prognosis.
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影响因子：
9.8
作者：
Delvecchio, Maurizio;De Bellis, Annamaria;Cavallo, Luciano
通讯作者：
Cavallo, Luciano
影响因子：
2
作者：
Bramanti E;Cicciù M;Matacena G;Costa S;Magazzù G
通讯作者：
Magazzù G
影响因子：
1.9
作者：
FERGUSON, R;HOLMES, GKT;COOKE, WT
通讯作者：
COOKE, WT
影响因子：
3.2
作者：
Delvecchio, Maurizio;Faienza, Maria Felicia;Cavallo, Luciano
通讯作者：
Cavallo, Luciano
影响因子：
1.9
作者：
Addolorato, G;Capristo, E;Gasbarrini, G
通讯作者：
Gasbarrini, G