Physiological identification of the human pedunculopontine nucleus.
Physiological identification of the human pedunculopontine nucleus.
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DOI：
10.1136/jnnp.2009.179069
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发表时间：
2010-01
期刊：
影响因子：
--
通讯作者：
Starr PA
中科院分区：
文献类型：
--
作者：
Shimamoto SA;Larson PS;Ostrem JL;Glass GA;Turner RS;Starr PA
The pedunculopontine nucleus (PPN) is a brainstem structure with widespread connections to the basal ganglia. Despite the recent introduction of PPN deep brain stimulation (DBS) for the treatment of gait disorders, little is known about its physiology in humans. We analyzed the discharge characteristics of single neurons in the PPN region in four patients and PPN local field potentials (LFP) in one patient, recorded during the course of DBS implantation. Two patients had Parkinson’s disease and two had non-sinemet responsive parkinsonism. Cell locations were plotted in the coordinate system of a human brainstem atlas. Fifty-six units in the PPN region were studied, of which 32 mapped to within PPN boundaries. The mean (+/− SD) discharge rate of neurons in the PPN was 23.2 (+/− 15.6) Hz. Spontaneous neuronal firing rate and burst discharge rate were significantly different between neurons in the region dorsal to PPN and those in the PPN. Responses to passive movement of contralateral and ipsilateral limbs were found. Theta and beta band oscillations were present in the PPN LFP. PPN discharge characteristics may prove useful in the electrophysiologic identification of PPN during DBS implantation surgery.
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1.7
作者：
GRUNWERG, BS;KREIN, H;KRAUTHAMER, GM
通讯作者：
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