Does Intra-Uterine Exposure to the Zika Virus Increase Risks of Cognitive Delay at Preschool Ages? Findings from a Zika-Exposed Cohort from Grenada, West Indies.
Does Intra-Uterine Exposure to the Zika Virus Increase Risks of Cognitive Delay at Preschool Ages? Findings from a Zika-Exposed Cohort from Grenada, West Indies.
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DOI：
10.3390/v15061290
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发表时间：
2023-05-30
期刊：
影响因子：
--
通讯作者：
Blackmon K
中科院分区：
文献类型：
--
作者：
Fernandes M;Evans R;Cheng M;Landon B;Noël T;Macpherson C;Cudjoe N;Burgen KS;Waechter R;LaBeaud AD;Blackmon K
母亲感染寨卡病毒(ZIKV)与一种独特的出生缺陷模式有关，称为先天性寨卡综合征(CZS)。在没有CZS的ZIKV暴露儿童中，通常不清楚他们是否受到了宫内感染和神经趋向性的保护。早期神经发育评估对于检测神经发育迟缓(NDDS)和优先对高危儿童进行早期干预至关重要。我们比较了ZIKV暴露和未暴露儿童在1、3和4岁时的神经发育结果，以评估暴露相关的NDD风险。在西印度群岛格林纳达的寨卡病毒活跃传播期间(2016-2017年)，共有384对母婴登记在册。暴露状况是基于对产前和出生后母亲血清的实验室评估。分别在12(n=66)、36(n=58)和48(n=59)个月时使用牛津神经发育评估、Net SY®第二版和加的夫视力测试评估神经发育。在接触ZIKV和未接触ZIKV的儿童之间，NDD的发生率和视力得分没有差异。出生时小头畸形症的发生率(0.88%比0.83%，p=0.81)以及儿童发育迟缓和消瘦的发生率在不同组之间没有差异。我们的结果表明，接触ZIKV病毒的儿童，其中大多数没有小头畸形，至少4岁以下的神经发育结果与未接触ZIKV的对照组相似。
Maternal infection with Zika virus (ZIKV) is associated with a distinct pattern of birth defects, known as congenital Zika syndrome (CZS). In ZIKV-exposed children without CZS, it is often unclear whether they were protected from in utero infection and neurotropism. Early neurodevelopmental assessment is essential for detecting neurodevelopmental delays (NDDs) and prioritizing at-risk children for early intervention. We compared neurodevelopmental outcomes between ZIKV-exposed and unexposed children at 1, 3 and 4 years to assess exposure-associated NDD risk. A total of 384 mother–child dyads were enrolled during a period of active ZIKV transmission (2016–2017) in Grenada, West Indies. Exposure status was based on laboratory assessment of prenatal and postnatal maternal serum. Neurodevelopment was assessed using the Oxford Neurodevelopment Assessment, the NEPSY® Second Edition and Cardiff Vision Tests, at 12 (n = 66), 36 (n = 58) and 48 (n = 59) months, respectively. There were no differences in NDD rates or vision scores between ZIKV-exposed and unexposed children. Rates of microcephaly at birth (0.88% vs. 0.83%, p = 0.81), and childhood stunting and wasting did not differ between groups. Our results show that Grenadian ZIKV-exposed children, the majority of whom were without microcephaly, had similar neurodevelopmental outcomes to unexposed controls up to at least an age of 4 years.
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DOI：
10.1016/s0140-6736(16)31389-7
发表时间：
2017-01-07
期刊：
Lancet (London, England)
影响因子：
--
作者：
Black MM;Walker SP;Fernald LCH;Andersen CT;DiGirolamo AM;Lu C;McCoy DC;Fink G;Shawar YR;Shiffman J;Devercelli AE;Wodon QT;Vargas-Barón E;Grantham-McGregor S;Lancet Early Childhood Development Series Steering Committee
通讯作者：
Lancet Early Childhood Development Series Steering Committee
影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.1155/2018/4635647
发表时间：
2018-01-01
影响因子：
2.8
作者：
Brenciaglia, Marco;Noel, Trevor P.;Macpherson, Calum N. L.
通讯作者：
Macpherson, Calum N. L.
影响因子：
3.5
作者：
Aragao, M. F. V. V.;Holanda, A. C.;Costello, A.
通讯作者：
Costello, A.
影响因子：
2.8
作者：
Pacheco O;Newton SM;Daza M;Cates JE;Reales JAM;Burkel VK;Mercado M;Godfred-Cato S;Gonzalez M;Anderson KN;Woodworth KR;Valencia D;Tong VT;Gilboa SM;Osorio MB;Rodríguez DYS;Prieto-Alvarado FE;Moore CA;Honein MA;Ospina Martínez ML
通讯作者：
Ospina Martínez ML