Gustatory neural pathways revealed by genetic tracing from taste receptor cells.
Gustatory neural pathways revealed by genetic tracing from taste receptor cells.
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DOI：
10.1271/bbb.130117
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Matsumoto I
中科院分区：
文献类型：
--
作者：
Matsumoto I
味觉感受器细胞遇到食物中的化学物质，并将这些信息传递到味觉神经元，再由味觉神经元进一步传递到脑干下部的味觉中继核。确定外周和中枢神经系统中参与味觉信息传输的神经元的特征有助于我们更好地理解我们如何感知和辨别味道。然而，很难从解剖学上识别它们。使用特定细胞类型的启动子/增强子和跨神经元示踪剂，我们产生了转基因小鼠来可视化味觉神经通路中的神经元。我们在嗅觉神经元投射的延髓内的头感觉神经节神经元和孤束核内观察到该示踪剂。该示踪剂也分布在网状结构和延髓中的几个运动核中，这些核尚未被识别为味觉上升通路。这些转基因小鼠发现了已知的味觉上升通路中的味觉中继神经元，以及一种意想不到的、因此可能是新颖的味觉系统神经回路。
Taste receptor cells encounter chemicals in foods and transmit this information to the gustatory neurons, which convey it further to the gustatory relay nuclei in the lower brainstem. Characterizing neurons involved in the transmission of gustatory information in the peripheral and central nervous systems helps us better understand how we perceive and discriminate tastes. However, it is difficult to anatomically identify them. Using cell-type-specific promoters/enhancers and a transneuronal tracer, we generated transgenic mice to visualize neurons in the gustatory neural pathways. We observed the tracer in the neurons of cranial sensory ganglia and the nucleus of the solitary tract in the medulla where gustatory neurons project. The tracer was also distributed in the reticular formation and several motor nuclei in the medulla that have not been recognized as gustatory ascending pathways. These transgenic mice revealed gustatory relay neurons in the known gustatory ascending pathway and an unexpected, thus presumably novel, neural circuit of gustatory system.
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