Common strategies for antigenic variation by bacterial, fungal and protozoan pathogens.
Common strategies for antigenic variation by bacterial, fungal and protozoan pathogens.
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DOI：
10.1038/nrmicro2145
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发表时间：
2009-07
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
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感染性生物与其宿主之间的复杂关系往往反映了病原体增殖和传播到新宿主的持续斗争，以及受感染个体控制和可能根除感染群体的需要。就哺乳动物和感染它们的病原体而言，一场名副其实的“军备竞赛”随之而来。一个高度适应的免疫系统已经进化到控制感染性生物的增殖，病原体已经发展出相应的复杂遗传系统来逃避这种免疫反应。在这里，我们回顾了来自遥远进化谱系的细菌、原生动物和真菌病原体如何进化出惊人的相似抗原变异机制，以避免被宿主免疫系统根除，从而维持持续感染，从而确保它们传播给新宿主。
The complex relationships between infectious organisms and their hosts often reflect the continuing struggle of the pathogen to proliferate and spread to new hosts, and the need of the infected individual to control and potentially eradicate the infecting population. In the case of mammals and the pathogens that infect them, a veritable “arms race” has ensued. A highly adapted immune system has evolved to control the proliferation of infectious organisms and the pathogens have developed correspondingly complex genetic systems to evade this immune response. Here, we review how bacterial, protozoan and fungal pathogens from distant evolutionary lineages have evolved surprisingly similar mechanisms of antigenic variation to avoid eradication by the host immune system and thus maintain persistent infections, thereby ensuring their transmission to new hosts.
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影响因子：
64.5
作者：
BARUCH, DI;PASLOSKE, BL;HOWARD, RJ
通讯作者：
HOWARD, RJ
DOI：
10.1073/pnas.0605302103
发表时间：
2006-11-28
影响因子：
11.1
作者：
Barbour, Alan G.;Dai, Qiyuan;Frank, Steven A.
通讯作者：
Frank, Steven A.
影响因子：
9.4
作者：
Brinkman, MB;McKevitt, M;Palzkill, T
通讯作者：
Palzkill, T
影响因子：
15.3
作者：
BOUHAROUNTAYOUN, H;OEUVRAY, C;DRUILHE, P
通讯作者：
DRUILHE, P
影响因子：
64.5
作者：
BERNARDS, A;VANDERPLOEG, LHT;CROSS, GAM
通讯作者：
CROSS, GAM