Ecotoxico-lipidomics: An emerging concept to understand chemical-metabolic relationships in comparative fish models.
Ecotoxico-lipidomics: An emerging concept to understand chemical-metabolic relationships in comparative fish models.
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DOI：
10.1016/j.cbd.2020.100742
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Martyniuk CJ
中科院分区：
文献类型：
--
作者：
Dreier DA;Bowden JA;Aristizabal-Henao JJ;Denslow ND;Martyniuk CJ
脂质在发育、稳态功能、免疫信号、生殖和生长中起着重要作用。虽然很明显，脂质生物合成和代谢的变化会影响生物体的生理，很少有研究确定环境压力如何影响脂质途径，更不用说改变鱼类的整体脂质分布。这是一个重大的研究空白，因为许多环境污染物与脂质信号传导和代谢途径相互作用。在这篇综述中，我们强调了脂质组学作为环境毒理学工具的实用性，讨论了化学脂质组学扰动的知识现状。与大多数卵生动物一样，卵母细胞发育期间脂质的加工和储存对鱼类胚胎发生也特别重要。以大口黑鲈（Micropterus salmoides）为例，转录组学数据表明，各种化学物质改变脂质代谢和调节，强调需要更复杂的调查如何毒物影响脂质反应。我们还指出了未来的挑战;这些挑战包括缺乏对鱼类中脂质加工和信号传导、组织和物种特异性脂质组成以及外来因素（例如，营养，温度）混淆解释。例如，毒物暴露可导致氧化应激和脂质过氧化，导致复杂的脂质副产物，难以测量。随着脂质组学在系统毒理学中的出现，多组学方法有望更清楚地定义对生理学的影响，在多个分子实体（基因-蛋白质-脂质/代谢物）之间建立更强的联系。离子迁移质谱和臭氧诱导解离等新技术的发展和实施支持脂质分子的完整结构解析。这对不良结果途径框架有影响，这将通过将这些细胞变化与更高水平的生物组织效应联系起来，增强脂质组学在毒理学中的应用。
Lipids play an essential role in development, homeostatic functions, immune signaling, reproduction, and growth. Although it is evident that changes in lipid biosynthesis and metabolism can affect organismal physiology, few studies have determined how environmental stressors affect lipid pathways, let alone alter global lipid profiles in fish. This is a significant research gap, as a number of environmental contaminants interact with lipid signaling and metabolic pathways. In this review, we highlight the utility of lipidomics as a tool in environmental toxicology, discussing the current state of knowledge regarding chemical-lipidomic perturbations. As with most oviparous animals, the processing and storage of lipids during oocyte development is also particularly important for embryogenesis in fish. Using largemouth bass (Micropterus salmoides) as an example, transcriptomics data suggest that various chemicals alter lipid metabolism and regulation, highlighting the need for more sophisticated investigations into how toxicants impact lipid responses. We also point out the challenges ahead; these include a lack of understanding about lipid processing and signaling in fish, tissue and species-specific lipid composition, and extraneous factors (e.g., nutrition, temperature) that confound interpretation. For example, toxicant exposure can lead to oxidative stress and lipid peroxidation, resulting in complex lipid byproducts that are challenging to measure. With the emergence of lipidomics in system toxicology, multi-omics approaches are expected to more clearly define effects on physiology, creating stronger linkages between multiple molecular entities (gene-protein-lipid/metabolite). The development and implementation of novel technologies such as ion mobility-mass spectrometry and ozone-induced dissociation support the complete structural elucidation of lipid molecules. This has implications in the adverse outcome pathway framework, which will enhance the application of lipidomics in toxicology by linking these cellular changes to effects at higher levels of biological organization.
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DOI：
10.1093/toxsci/kfx097
发表时间：
2017-08-01
期刊：
Toxicological sciences : an official journal of the Society of Toxicology
影响因子：
--
作者：
Brockmeier EK;Hodges G;Hutchinson TH;Butler E;Hecker M;Tollefsen KE;Garcia-Reyero N;Kille P;Becker D;Chipman K;Colbourne J;Collette TW;Cossins A;Cronin M;Graystock P;Gutsell S;Knapen D;Katsiadaki I;Lange A;Marshall S;Owen SF;Perkins EJ;Plaistow S;Schroeder A;Taylor D;Viant M;Ankley G;Falciani F
通讯作者：
Falciani F
影响因子：
14.9
作者：
Davis AP;Grondin CJ;Johnson RJ;Sciaky D;McMorran R;Wiegers J;Wiegers TC;Mattingly CJ
通讯作者：
Mattingly CJ
影响因子：
4.5
作者：
Colli-Dula, Reyna-Cristina;Martyniuk, Christopher J.;Kroll, Kevin J.;Prucha, Melinda S.;Kozuch, Marianne;Barber, David S.;Denslow, Nancy D.
通讯作者：
Denslow, Nancy D.
DOI：
10.1093/bioinformatics/bty679
发表时间：
2019-02-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Fahy E;Alvarez-Jarreta J;Brasher CJ;Nguyen A;Hawksworth JI;Rodrigues P;Meckelmann S;Allen SM;O'Donnell VB
通讯作者：
O'Donnell VB
影响因子：
6.5
作者：
Choi, Jaewoo;Leonard, Scott W.;Traber, Maret G.
通讯作者：
Traber, Maret G.