LipidFinder on LIPID MAPS: peak filtering, MS searching and statistical analysis for lipidomics.
LipidFinder on LIPID MAPS: peak filtering, MS searching and statistical analysis for lipidomics.
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DOI:
10.1093/bioinformatics/bty679
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发表时间:
2019-02-15
期刊:
影响因子:
--
通讯作者:
O'Donnell VB
中科院分区:
文献类型:
--
作者:
Fahy E;Alvarez-Jarreta J;Brasher CJ;Nguyen A;Hawksworth JI;Rodrigues P;Meckelmann S;Allen SM;O'Donnell VB
We present LipidFinder online, hosted on the LIPID MAPS website, as a liquid chromatography/mass spectrometry (LC/MS) workflow comprising peak filtering, MS searching and statistical analysis components, highly customized for interrogating lipidomic data. The online interface of LipidFinder includes several innovations such as comprehensive parameter tuning, a MS search engine employing in-house customized, curated and computationally generated databases and multiple reporting/display options. A set of integrated statistical analysis tools which enable users to identify those features which are significantly-altered under the selected experimental conditions, thereby greatly reducing the complexity of the peaklist prior to MS searching is included. LipidFinder is presented as a highly flexible, extensible user-friendly online workflow which leverages the lipidomics knowledge base and resources of the LIPID MAPS website, long recognized as a leading global lipidomics portal. LipidFinder on LIPID MAPS is available at: http://www.lipidmaps.org/data/LF.
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影响因子:
3.5
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20.1
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O'Connor, Anne;Brasher, Christopher J.;O'Donnell, Valerie B.
通讯作者:
O'Donnell, Valerie B.