LipidFinder on LIPID MAPS: peak filtering, MS searching and statistical analysis for lipidomics.

LipidFinder on LIPID MAPS: peak filtering, MS searching and statistical analysis for lipidomics.
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DOI:
10.1093/bioinformatics/bty679
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发表时间:
2019-02-15
期刊:
Bioinformatics (Oxford, England)
影响因子:
--
通讯作者:
O'Donnell VB
O'Donnell VB
中科院分区:
其他
文献类型:
--
作者:
Fahy E;Alvarez-Jarreta J;Brasher CJ;Nguyen A;Hawksworth JI;Rodrigues P;Meckelmann S;Allen SM;O'Donnell VB

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我们在 LIPID MAPS 网站上在线展示 LipidFinder,作为液相色谱/质谱 (LC/MS) 工作流程,包括峰过滤、MS 搜索和统计分析组件,高度定制用于查询脂质组学数据。 LipidFinder 的在线界面包括多项创新,例如全面的参数调整、采用内部定制、策划和计算生成的数据库的 MS 搜索引擎以及多个报告/显示选项。包括一组集成的统计分析工具,使用户能够识别在选定的实验条件下显着改变的特征,从而大大降低 MS 搜索之前峰列表的复杂性。 LipidFinder 是一个高度灵活、可扩展、用户友好的在线工作流程,它利用了 LIPID MAPS 网站的脂质组学知识库和资源,该网站长期以来被认为是全球领先的脂质组学门户。 LIPID MAPS 上的 LipidFinder 可从以下网址获取:http://www.lipidmaps.org/data/LF。
We present LipidFinder online, hosted on the LIPID MAPS website, as a liquid chromatography/mass spectrometry (LC/MS) workflow comprising peak filtering, MS searching and statistical analysis components, highly customized for interrogating lipidomic data. The online interface of LipidFinder includes several innovations such as comprehensive parameter tuning, a MS search engine employing in-house customized, curated and computationally generated databases and multiple reporting/display options. A set of integrated statistical analysis tools which enable users to identify those features which are significantly-altered under the selected experimental conditions, thereby greatly reducing the complexity of the peaklist prior to MS searching is included. LipidFinder is presented as a highly flexible, extensible user-friendly online workflow which leverages the lipidomics knowledge base and resources of the LIPID MAPS website, long recognized as a leading global lipidomics portal. LipidFinder on LIPID MAPS is available at: http://www.lipidmaps.org/data/LF.
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