Differential mitochondrial DNA copy number in three mood states of bipolar disorder.
Differential mitochondrial DNA copy number in three mood states of bipolar disorder.
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双相情感障碍三种情绪状态下线粒体 DNA 拷贝数的差异。
DOI：
10.1186/s12888-018-1717-8
复制
发表时间：
2018-05-25
期刊：
影响因子：
4.4
通讯作者：
Chen X
中科院分区：
文献类型：
--
作者：
Wang D;Li Z;Liu W;Zhou J;Ma X;Tang J;Chen X
越来越多的证据表明线粒体异常与双相情感障碍有关。线粒体DNA拷贝数（mtDNA copy number，mtDNA Acn）作为线粒体功能和生物发生的敏感指标，可能参与双相情感障碍的病理生理过程。采用定量聚合酶链反应测定了131例有躁狂、抑郁和正常情绪症状的BD患者的白细胞相对mtDNA。34名健康人作为对照。采用Young躁狂量表（YMRS）、汉密尔顿抑郁量表（HAM-D）、临床疗效总评量表-双相情感障碍-疾病严重程度量表（CGI-BD-S）、阳性和阴性症状量表（PANSS）评定BD的临床症状。与健康对照组相比，具有躁狂和抑郁症状的BD患者呈现显著降低的mtDNA水平（p值分别为0.009和0.041）。正常胸腺患者和健康对照组之间的mtDNAc n无显著性差异。在躁狂患者中，mtDNAcn与复发次数呈负相关（β =-0.341，p = 0.044）。我们的研究描述了第一个证据：（1）躁狂BD患者的mtDNA水平显著下降，（2）躁狂和抑郁BD患者的mtDNA水平相似，（3）躁狂状态患者的mtDNA水平与复发次数呈负相关。躁狂和抑郁患者的mtDNAc n改变可能反映了能量代谢紊乱，支持线粒体异常在BD病理生理学中的作用。本文的在线版本（10.1186/s12888-018-1717-8）包含补充材料，可供授权用户使用。
Accumulating evidences indicated that mitochondrial abnormalities were associated with bipolar disorder. As a sensitive index of mitochondrial function and biogenesis, Mitochondrial DNA copy number (mtDNAcn) may be involved in the pathophysiology of bipolar disorder. Leukocyte relative mtDNAcn was measured by quantitative polymerase chain reaction in subjects with BD (n = 131) in manic, depressive, and euthymic symptoms. Thirty-four healthy individuals were used as comparison control. BD clinical symptomatology was evaluated by Young Mania Rating Scale (YMRS), Hamilton Depression Scale (HAM-D), Clinical Global Impression-Bipolar Disorder-Severity of Illness Scale (CGI-BD-S), and the Positive and Negative Syndrome Scale (PANSS). Compared to healthy controls, BD patients with manic and depressive symptoms presented significantly decreased mtDNAcn levels (p-value = 0.009 and 0.041, respectively). No significant differences were detected in mtDNAcn between euthymic patients and healthy controls. The mtDNAcn was negatively correlated with the number of relapses in manic patients (β = − 0.341, p = 0.044). Our study described the first evidence of (1) a significant decline of mtDNAcn in manic BD patients, (2) a similar decreased level of mtDNAcn between manic and depressed BD patients, (3) a negative correlation of mtDNAcn with number of relapses in patients suffering from manic states. Alterations of mtDNAcn in manic and depressed patients, which may reflect disturbances of energy metabolism, supported the role of mitochondrial abnormalities in the pathophysiology of BD. The online version of this article (10.1186/s12888-018-1717-8) contains supplementary material, which is available to authorized users.
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DOI：
10.1016/j.bbadis.2009.09.002
发表时间：
2010-01
影响因子：
6.2
作者：
Niizuma, Kuniyasu;Yoshioka, Hideyuki;Chen, Hai;Kim, Gab Seok;Jung, Joo Eun;Katsu, Masataka;Okami, Nobuya;Chan, Pak H.
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影响因子：
6.8
作者：
Munkholm K;Peijs L;Vinberg M;Kessing LV
通讯作者：
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影响因子：
5.6
作者：
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影响因子：
4.6
作者：
Li Z;Hu M;Zong X;He Y;Wang D;Dai L;Dong M;Zhou J;Cao H;Lv L;Chen X;Tang J
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DOI：
10.1017/s1461145705005213
发表时间：
2005-12-01
影响因子：
4.8
作者：
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