Hypertension contributes to exacerbated osteoarthritis pathophysiology in rats in a sex-dependent manner.
Hypertension contributes to exacerbated osteoarthritis pathophysiology in rats in a sex-dependent manner.
复制标题
DOI：
10.1186/s13075-022-02966-9
复制
发表时间：
2023-01-12
影响因子：
4.9
通讯作者：
中科院分区：
文献类型：
--
作者：
高血压是骨关节炎（OA）的常见合并症，伴有已知的自主神经失调;因此，自主神经系统可能提供了一个共同的潜在机制。本研究的目的是检查自主神经系统在OA和高血压临床前模型中的作用。实验在自发性高血压大鼠和血压正常的对照品系（包括雄性和雌性大鼠）中进行。通过内侧半月板横断手术诱导OA，皮肤切口用作假手术对照（n = 7-8/品系/性别/手术）。在基线时测量触觉敏感度、焦虑相关行为和血清皮质酮，然后在8周内每两周测量一次。在第9-10周，测定对化学迷走神经激动剂的心血管反应以间接评估迷走神经功能。通过组织学切片分级评估关节结构。在男性中，OA导致高血压（OA与非OA p < 0.001）和血压正常（OA与非OA p < 0.001）的软骨变薄。仅患有高血压和OA共病的女性显示软骨较薄（p = 0.013）。与血压正常的OA动物相比，雄性高血压OA动物具有增加的钙化的软骨下骨（p = 0.043），而雌性高血压OA动物与高血压假手术动物相比具有增加的钙化的软骨下骨（p < 0.001）。所有MCLT+MMT组均发生轻度滑膜炎;有趣的是，高血压OA女性的滑膜炎评分高于血压正常的OA女性（p = 0.046）。此外，高血压导致OA（高血压与正常血压p = 0.018）和假手术（高血压与正常血压p < 0.001）雄性动物中迷走神经激活的血压下降幅度更大。在雌性动物中，这种趋势仅适用于OA动物（血压正常vs.高血压p = 0.005）。这些数据提供了初步证据表明，高血压影响OA的进展，并鼓励进一步研究自主神经系统作为一种可能的机制。在线版本包含补充材料，可通过10.1186/s13075-022-02966-9获得。
Hypertension is a common comorbidity of osteoarthritis (OA) with known autonomic dysregulation; thus, the autonomic nervous system may provide a shared underlying mechanism. The objective of this study was to examine the role of the autonomic nervous system in a preclinical model of OA and hypertension. Experiments were conducted in spontaneously hypertensive rats and a normotensive control strain, including male and female rats. OA was surgically induced via medial meniscus transection with skin incision used as a sham control (n = 7–8/strain/sex/surgery). Tactile sensitivity, anxiety-related behavior, and serum corticosterone were measured at baseline then bi-weekly across 8 weeks. At weeks 9–10, cardiovascular responses to a chemical vagal nerve agonist were determined to indirectly evaluate vagus nerve function. The joint structure was assessed via grading of histological sections. In males, OA resulted in thinner cartilage in both hypertensive (OA vs. non-OA p < 0.001) and normotensive (OA vs. non-OA p < 0.001). Only females with comorbid hypertension and OA displayed thinner cartilage (p = 0.013). Male hypertensive OA animals had increased calcified subchondral bone compared to normotensive OA animals (p = 0.043) while female hypertensive OA animals had increased calcified subchondral bone compared to hypertensive sham animals (p < 0.001). All MCLT+MMT groups developed low-grade synovitis; interestingly, hypertensive OA females had higher synovitis scores than normotensive OA females (p = 0.046). Additionally, hypertension led to larger drops in blood pressure with vagal activation in both OA (hypertensive vs. normotensive p = 0.018) and sham (hypertensive vs. normotensive p < 0.001) male animals. In females, this trend held true only in OA animals (normotensive vs. hypertensive p = 0.005). These data provide preliminary evidence that hypertension influences OA progression and encourages further study into the autonomic nervous system as a possible mechanism. The online version contains supplementary material available at 10.1186/s13075-022-02966-9.
登录
查看更多内容
影响因子：
2.7
作者：
Bekhbat M;Merrill L;Kelly SD;Lee VK;Neigh GN
通讯作者：
Neigh GN
DOI：
10.1016/j.autneu.2017.09.003
发表时间：
2017-12
期刊：
Autonomic neuroscience : basic & clinical
影响因子：
--
作者：
Adlan AM;Veldhuijzen van Zanten JJCS;Lip GYH;Paton JFR;Kitas GD;Fisher JP
通讯作者：
Fisher JP
DOI：
10.1016/j.ocarto.2020.100026
发表时间：
2020-03
期刊：
Osteoarthritis and cartilage open
影响因子：
--
作者：
Andriacchi, Thomas P;Griffin, Timothy M;Loeser, Richard F Jr;Chu, Constance R;Roos, Ewa M;Hawker, Gillian A;Erhart-Hledik, Jennifer C;Fischer, Arielle G
通讯作者：
Fischer, Arielle G
影响因子：
7
作者：
Hwang, H. S.;Park, I. Y.;Kim, H. A.
通讯作者：
Kim, H. A.
影响因子：
3.4
作者：
Lo GH;McAlindon TE;Katz JN;Driban JB;Price LL;Eaton CB;Petersen NJ;Ballantyne CM;Suarez-Almazor ME
通讯作者：
Suarez-Almazor ME