Novel imaging techniques for cystic fibrosis lung disease.
Novel imaging techniques for cystic fibrosis lung disease.
复制标题
囊性纤维化肺病的新成像技术。
DOI：
10.1002/ppul.24931
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发表时间：
2021-03
影响因子：
3.1
通讯作者：
Woods JC
中科院分区：
文献类型：
--
作者：
Goralski JL;Stewart NJ;Woods JC
随着越来越多的囊性纤维化 (CF) 患者接受高效 CFTR（囊性纤维化跨膜调节蛋白）调节剂治疗，尤其是年轻患者，越来越需要确定能够检测和局部可视化轻度 CF 肺部疾病和疾病状态细微变化的成像工具。在这篇综述中，我们讨论了 CF 临床医生和研究人员可用的肺部结构和功能成像模式的最新发展，从广泛使用的、临床上用于评估 CF 肺部疾病的成像方法（胸部放射线照相和计算机断层扫描）到即将成为下一阶段临床工具的新技术——结构/功能质子和超极化气体磁共振成像 (MRI)。最后，我们简要讨论了几种目前仅在选定的研究环境中可用的较新的肺部成像技术，包括胸部断层扫描和氟化气体 MRI。我们提供每种技术的临床和/或研究状态的最新信息，重点是敏感性、早期疾病检测以及监测治疗效果的可能性。
With an increasing number of patients with cystic fibrosis (CF) receiving highly effective CFTR (cystic fibrosis transmembrane regulator protein) modulator therapy, particularly at a young age, there is an increasing need to identify imaging tools that can detect and regionally visualize mild CF lung disease and subtle changes in disease state. In this review, we discuss the latest developments in imaging modalities for both structural and functional imaging of the lung available to CF clinicians and researchers, from the widely available, clinically utilized imaging methods for assessing CF lung disease—chest radiography and computed tomography—to newer techniques poised to become the next phase of clinical tools—structural/functional proton and hyperpolarized gas magnetic resonance imaging (MRI). Finally, we provide a brief discussion of several newer lung imaging techniques that are currently available only in selected research settings, including chest tomosynthesis, and fluorinated gas MRI. We provide an update on the clinical and/or research status of each technique, with a focus on sensitivity, early disease detection, and possibilities for monitoring treatment efficacy.
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