Subdissociative dose ketamine produces a deficit in manipulation but not maintenance of the contents of working memory.
Subdissociative dose ketamine produces a deficit in manipulation but not maintenance of the contents of working memory.
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DOI：
10.1038/sj.npp.1300272
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发表时间：
2003-11
影响因子：
7.6
通讯作者：
Fletcher, P
中科院分区：
文献类型：
--
作者：
Honey, RAE;Turner, DC;Honey, GD;Sharar, SR;Kumaran, D;Pomarol-Clotet, E;McKenna, P;Sahakian, B;Robbins, TW;Fletcher, P
我们研究了亚解离剂量氯胺酮对工作记忆任务期间执行过程的影响。共有 11 名健康志愿者参与了一项双盲、安慰剂对照、随机、受试者内研究。他们参加了三次，接受静脉注射安慰剂、较低剂量的氯胺酮和较高剂量的氯胺酮。每次，他们都经历了一系列涉及言语和视觉空间领域工作记忆功能的任务。进一步的任务探索了长期记忆、计划、注意力和知觉处理的各个方面。在工作记忆/执行功能方面，观察到了高度特异性的损伤模式。仅在较高剂量的氯胺酮下才会出现损害，并且仅限于言语工作记忆任务的一个亚组：虽然视觉空间工作记忆没有显示出损害的证据，并且言语工作记忆期间的简单维护过程也未受到损害，但较高剂量的氯胺酮对工作记忆中的信息操作产生了显着的损害。氯胺酮的这种特定过程的作用反映在药物与任务的相互作用中。这种氯胺酮效应的特异性表明，NMDA 受体阻断的最早效应是执行功能的高级控制，而不是更基本的维持过程。
We investigated the effects of subdissociative dose ketamine on executive processes during a working memory task. A total of 11 healthy volunteers participated in a double-blind, placebo-controlled, randomized, within-subjects study. They attended on three occasions, receiving intravenous infusions of placebo, a lower ketamine dose, and a higher ketamine dose. On each occasion, they underwent a series of tasks engaging working memory function in verbal and visuo-spatial domains. Further tasks explored aspects of long-term memory, planning, attention, and perceptual processing. With respect to working memory/executive function, a highly specific pattern of impairment was observed. Impairments were seen only at the higher dose of ketamine and restricted to a subgroup of the verbal working memory tasks: While visuo-spatial working memory showed no evidence of impairment, and while simple maintenance processes during verbal working memory were also unimpaired, higher dose ketamine produced a significant impairment in the manipulation of information within working memory. This process-specific effect of ketamine was reflected in a drug-by-task interaction. The specificity of this ketamine effect suggests that the earliest effect of NMDA receptor blockade is in higher order control of executive function rather than in more basic maintenance processes.
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影响因子：
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作者：
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通讯作者：
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