High-but not moderate-intensity exercise acutely attenuates hypercapnia-induced vasodilation of the internal carotid artery in young men
High-but not moderate-intensity exercise acutely attenuates hypercapnia-induced vasodilation of the internal carotid artery in young men
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高强度但非中等强度的运动会急剧减弱年轻男性高碳酸血症引起的颈内动脉血管舒张
DOI：
10.1007/s00421-021-04721-5
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发表时间：
2021
影响因子：
3
通讯作者：
Iwamoto Erika
中科院分区：
文献类型：
--
作者：
Sakamoto Rintaro;Katayose Masaki;Yamada Yutaka;Neki Toru;Kamoda Tatsuki;Tamai Katsuyuki;Yamazaki Kotomi;Iwamoto Erika
不同运动强度下运动诱导的剪切率（SR）增加可能对高碳酸血症诱导的颈内动脉（ICA）血管舒张（脑血管功能的潜在指标）产生不同的影响。我们的目的是阐明运动强度的影响ICA SR在运动和运动后高碳酸血症引起的血管舒张的ICA在young men. MethodsTwelve健康男性完成了30分钟的自行车在中度[MIE; 65 ± 5%的年龄预测的最大心率（HRmax）]和高（HIE; 85 ± 5%HRmax）强度。高碳酸血症诱导的血管舒张由3分钟的高碳酸血症（目标潮气末分压CO2 + 10 mmHg）诱导，并在运动前、运动后5分钟和60分钟进行评估。多普勒超声被用来测量ICA直径和血流速度在运动和高碳酸血症tests.ResultsSR没有改变，在任何运动（时间的相互作用和主效应; bothP> 0.05）。ICA电导在HIE期间从静息值（5.1 ± 1.3至3.2 ± 1.0 mL·min-1·mmHg-1; P <0.01）下降，但在MIE期间没有下降（5.0 ± 1.3至4.0 ± 0.8 mL·min-1·mmHg-1; P = 0.11）。因此，高碳酸血症引起的血管舒张在HIE后立即下降（6.9 ± 1.7%至4.0 ± 1.4%; P <0.01），但在MIE后没有下降（7.2 ± 2.1%至7.3 ± 1.8%; P> 0.05）。运动后60分钟，高碳酸血症诱导的血管舒张在两项试验中均恢复至基线值（MIE 8.0 ± 3.1%; HIE 6.4 ± 2.9%;两者P> 0.05）。鉴于急性反应部分与外周内皮功能的适应性反应有关，有氧训练对脑血管健康的影响可能因运动强度而异。
PurposeExercise-induced increases in shear rate (SR) across different exercise intensities may differentially affect hypercapnia-induced vasodilation of the internal carotid artery (ICA), a potential index of cerebrovascular function. We aimed to elucidate the effects of exercise intensity on ICA SR during exercise and post-exercise hypercapnia-induced vasodilation of the ICA in young men.MethodsTwelve healthy men completed 30 min of cycling at moderate [MIE; 65 ± 5% of age-predicted maximal heart rate (HRmax)] and high (HIE; 85 ± 5% HRmax) intensities. Hypercapnia-induced vasodilation was induced by 3 min of hypercapnia (target end-tidal partial pressure of CO2+ 10 mmHg) and was assessed at pre-exercise, 5 min and 60 min after exercise. Doppler ultrasound was used to measure ICA diameter and blood velocity during exercise and hypercapnia tests.ResultsSR was not altered during either exercise (interaction and main effects of time; bothP> 0.05). ICA conductance decreased during HIE from resting values (5.1 ± 1.3 to 3.2 ± 1.0 mL·min−1·mmHg−1;P< 0.01) but not during MIE (5.0 ± 1.3 to 4.0 ± 0.8 mL·min−1·mmHg−1;P= 0.11). Consequently, hypercapnia-induced vasodilation declined immediately after HIE (6.9 ± 1.7% to 4.0 ± 1.4%;P< 0.01), but not after MIE (7.2 ± 2.1% to 7.3 ± 1.8%;P> 0.05). Sixty minutes after exercise, hypercapnia-induced vasodilation returned to baseline values in both trials (MIE 8.0 ± 3.1%; HIE 6.4 ± 2.9%; bothP> 0.05).ConclusionThe present study showed blunted hypercapnia-induced vasodilation of the ICA immediately after high-intensity exercise, but not a moderate-intensity exercise in young men. Given that the acute response is partly linked to the adaptive response in the peripheral endothelial function, the effects of aerobic training on cerebrovascular health may vary depending on exercise intensity.
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影响因子：
8.3
作者：
Carter, Howard H.;Atkinson, Ceri L.;Green, Daniel J.
通讯作者：
Green, Daniel J.
影响因子：
3.3
作者：
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影响因子：
5.5
作者：
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通讯作者：
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影响因子：
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作者：
Dawson, Ellen A.;Green, Daniel J.;Thijssen, Dick H. J.
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评估用于测量人类休息和运动期间脑血流量的方法
影响因子：
3
作者：
M. Tymko;P. Ainslie;Kurt J. Smith
通讯作者：
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