Metabolic consequences of hepatic steatosis in overweight and obese adolescents.
Metabolic consequences of hepatic steatosis in overweight and obese adolescents.
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DOI：
10.2337/dc11-1754
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发表时间：
2012-04
期刊：
影响因子：
16.2
通讯作者：
McGavock JM
中科院分区：
文献类型：
--
作者：
Wicklow BA;Wittmeier KD;MacIntosh AC;Sellers EA;Ryner L;Serrai H;Dean HJ;McGavock JM
检验肝脏脂肪变性与超重和肥胖青年2型糖尿病危险因素相关的假设，由心肺适应性介导。这是一项横断面研究，比较了30名超重和肥胖青少年肝脂肪变性，68名超重和肥胖青少年无肝脂肪变性，11名健康体重青少年无肝脂肪变性的胰岛素敏感性。通过在自行车测力计上进行分级最大运动试验来确定呼吸适应性。次要结局包括代谢综合征的存在和对75 g口服葡萄糖挑战的葡萄糖反应。肝脂肪变性的存在与胰岛素敏感性降低55%（P = 0.02）和代谢综合征患病率增加两倍（P = 0.001）相关。在年龄、性别和内脏脂肪匹配后，两组之间的胰岛素敏感性（3.5和4.5 mU·kg-1·min-1，P = 0.03）、代谢综合征患病率（48和20%，P = 0.03）和葡萄糖曲线下面积（816和710，P = 0.04）仍然存在差异。肝脏脂肪变性与胰岛素敏感性（β =-0.24，t =-2.29，P < 0.025）、代谢综合征（β =-0.54，t =-5.8，P < 0.001）和葡萄糖曲线下面积（β = 0.33，t = 3.3，P < 0.001）之间的相关性与内脏和全身肥胖无关。呼吸适应性与肝脂肪变性、胰岛素敏感性或代谢综合征的存在无关。肝脏脂肪变性与2型糖尿病危险因素相关，与心肺功能、全身肥胖和内脏脂肪量无关。
To test the hypothesis that hepatic steatosis is associated with risk factors for type 2 diabetes in overweight and obese youth, mediated by cardiorespiratory fitness. This was a cross-sectional study comparing insulin sensitivity between 30 overweight and obese adolescents with hepatic steatosis, 68 overweight and obese adolescents without hepatic steatosis, and 11 healthy weight adolescents without hepatic steatosis. Cardiorespiratory fitness was determined by a graded maximal exercise test on a cycle ergometer. Secondary outcomes included presence of metabolic syndrome and glucose response to a 75-g oral glucose challenge. The presence of hepatic steatosis was associated with 55% lower insulin sensitivity (P = 0.02) and a twofold greater prevalence of metabolic syndrome (P = 0.001). Differences in insulin sensitivity (3.5 vs. 4.5 mU ⋅ kg−1 ⋅ min−1, P = 0.03), prevalence of metabolic syndrome (48 vs. 20%, P = 0.03), and glucose area under the curve (816 vs. 710, P = 0.04) remained between groups after matching for age, sex, and visceral fat. The association between hepatic steatosis and insulin sensitivity (β = −0.24, t = −2.29, P < 0.025), metabolic syndrome (β = −0.54, t = −5.8, P < 0.001), and glucose area under the curve (β = 0.33, t = 3.3, P < 0.001) was independent of visceral and whole-body adiposity. Cardiorespiratory fitness was not associated with hepatic steatosis, insulin sensitivity, or presence of metabolic syndrome. Hepatic steatosis is associated with type 2 diabetes risk factors independent of cardiorespiratory fitness, whole-body adiposity, and visceral fat mass.
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影响因子：
5.4
作者：
Boston, Ray C;Stefanovski, Darko;Bergman, Richard N
通讯作者：
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影响因子：
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作者：
D'Adamo E;Cali AM;Weiss R;Santoro N;Pierpont B;Northrup V;Caprio S
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