A survey of oral cavity afferents to the rat nucleus tractus solitarii.
A survey of oral cavity afferents to the rat nucleus tractus solitarii.
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DOI：
10.1002/cne.22715
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发表时间：
2012-02-15
影响因子：
2.5
通讯作者：
Erisir, Alev
中科院分区：
文献类型：
--
作者：
Corson, James;Aldridge, Alexandra;Wilmoth, Kristin;Erisir, Alev
可视化的有髓纤维的安排，细胞结构，和投射领域的传入纤维串联显示输入目标的选择性，确定细分的孤束核（NTS）。鼓索神经（CT）、岩浅大神经（GSP）和舌咽神经（IX）是支配口腔中味蕾的三种神经，其中央纤维显著地占据味觉敏感的嘴中央亚部。此外，CT和IX在头外侧亚部中支配和重叠，其主要由三叉神经（LV）的舌分支靶向。与CT终末野相比，在吻中央亚区，GSP更偏向吻侧和内侧，IX更偏向背侧和尾侧。而IX和LV弥漫性地填充吻外侧分区，CT仅投射到背侧和内侧部分。中间外侧细分接收来自IX和LV的输入，但不接收CT或GSP。在尾侧NTS中，腹外侧亚部接受来自CT、GSP和LV的显著神经支配，但不接受来自IX的神经支配。孤束内侧的尾侧亚核内无标记传入纤维。数据表明，每个神经内的纤维群对NTS功能不同的细分具有选择性，这凸显了CT在头外侧NTS中以及CT和GSP在尾侧NTS中具有同样不同功能的可能性。此外，这提供了一个有用的解剖学模板，研究口腔传入神经的NTS的味觉反应的细分，以及在细分，调节摄入和其他orthopathic行为的作用。
Visualization of myelinated fiber arrangements, cytoarchitecture, and projection fields of afferent fibers in tandem revealed input target selectivity in identified subdivisions of the nucleus tractus solitarii (NTS). The central fibers of the chorda tympani (CT), greater superficial petrosal (GSP), and glossopharyngeal (IX) nerves, three nerves that innervate taste buds in the oral cavity, prominently occupy the gustatorysensitive rostrocentral subdivision. In addition, CT and IX innervate and overlap in rostrolateral subdivision, which is primarily targeted by the lingual branch of the trigeminal nerve (LV). In rostrocentral subdivision, compared to the CT terminal field in rostrocentral subdivision, GSP appeared more rostral and medial, and IX was more dorsal and caudal. While IX and LV filled the rostrolateral subdivision diffusely, CT projected only to the dorsal and medial portions. The intermediate lateral subdivision received input from IX and LV but not CT or GSP. In the caudal NTS, the ventrolateral subdivision received notable innervation from CT, GSP, and LV, but not IX. No caudal subnuclei medial to solitary tract contained labeled afferent fibers. The data indicate selectivity of fiber populations within each nerve for functionally distinct subdivisions of the NTS, highlighting the possibility of equally distinct functions for CT in the rostrolateral NTS, and CT and GSP in the caudal NTS. Further, this provides a useful anatomical template to study the role of oral cavity afferents in the taste-responsive subdivision of the NTS as well as in subdivisions that regulate ingestion and other oromotor behaviors.
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影响因子：
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