Age of greatest susceptibility to childhood lead exposure: a new statistical approach.
Age of greatest susceptibility to childhood lead exposure: a new statistical approach.
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对儿童铅暴露最敏感的年龄：一种新的统计方法。
DOI：
10.1289/ehp.0800426
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发表时间：
2009-08
影响因子：
10.4
通讯作者：
Dietrich, Kim N.
中科院分区：
文献类型：
--
作者：
Hornung, Richard W.;Lanphear, Bruce P.;Dietrich, Kim N.
对铅毒性的敏感性通常被认为在幼儿期最大（例如，2岁），但最近的研究表明，5-7岁时的血铅浓度（BPb）与智商的关系更密切。我们的目的是确定年龄的最大易感性铅暴露使用一种创新的统计方法，避免相关的串行BPb测量的问题。我们分析了两个队列的儿童，从婴儿期到6岁，在纽约的罗切斯特（n = 211）和俄亥俄州的辛辛那提（n = 251）。当孩子们6岁时，测量了一系列的BPb水平，并进行了智商测试。在调整相关协变量后，将6年BPb与2年BPb的比值添加到多元回归模型中，以检验儿童期BPb曲线的模式是否对智商有额外的影响。当将6岁时的BPb与2岁时的BPb之比添加到包括平均儿童BPb的多元回归模型中时，显示出对智商的强烈影响（p <0.001）。与6岁时BPb比2岁时低50%的儿童相比，6岁时BPb比2岁时高50%的儿童智商下降7.0分。同样，对于6年BPb比2年BPb高50%的受试者，刑事逮捕率高出3.35倍。我们的结论是，6年的BPb与认知和行为发展的相关性比幼儿期测量的BPb更强。
Susceptibility to lead toxicity is often assumed to be greatest during early childhood (e.g., 2 years of age), but recent studies suggest that blood lead concentrations (BPb) taken at 5–7 years of age are more strongly associated with IQ. We aimed to determine the age of greatest susceptibility to lead exposure using an innovative statistical approach that avoids the problem of correlated serial BPb measurements. We analyzed two cohorts of children that were followed from infancy to 6 years of age in Rochester, New York (n = 211), and Cincinnati, Ohio (n = 251). Serial BPb levels were measured and IQ tests were done when children were 6 years of age. After adjustment for relevant covariates, the ratio of 6-year BPb to 2-year BPb was added to the multiple regression model to test whether the pattern of BPb profiles during childhood had additional effect on IQ. The ratio of BPb at 6 years to the BPb at 2 years showed a strong effect on IQ (p < .001) when added to the multiple regression model that included the average childhood BPb. IQ decreased by 7.0 points for children whose BPb at 6 years of age was 50% greater than that at 2 years compared with children whose 6-year BPb was 50% less than their 2-year BPb. Similarly, criminal arrest rates were a factor of 3.35 higher for those subjects whose 6-year BPb was 50% higher than their 2-year BPb. We conclude that 6-year BPb is more strongly associated with cognitive and behavioral development than is BPb measured in early childhood.
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影响因子：
2.9
作者：
Wasserman, GA;Liu, X;Graziano, JH
通讯作者：
Graziano, JH
影响因子：
15.8
作者：
Wright JP;Dietrich KN;Ris MD;Hornung RW;Wessel SD;Lanphear BP;Ho M;Rae MN
通讯作者：
Rae MN
影响因子：
158.5
作者：
Canfield, RL;Henderson, CR;Lanphear, BP
通讯作者：
Lanphear, BP
血液铅浓度<10 microg/dl和6岁的儿童智力。
影响因子：
10.4
作者：
Jusko, Todd A.;Henderson, ChaKes R., Jr.;Lanphear, Bruce P.;Cory-Slechta, Deborah A.;Parsons, Patrick J.;Canfield, Richard L.
通讯作者：
Canfield, Richard L.
影响因子：
2.9
作者：
DIETRICH, KN;BERGER, OG;BORNSCHEIN, RL
通讯作者：
BORNSCHEIN, RL