Two genetically diverse H7N7 avian influenza viruses isolated from migratory birds in central China.
Two genetically diverse H7N7 avian influenza viruses isolated from migratory birds in central China.
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从中国中部的候鸟中分离出两种基因多样化的 H7N7 禽流感病毒。
DOI：
10.1038/s41426-018-0064-7
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发表时间：
2018-04-11
影响因子：
13.2
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Liu H;Xiong C;Chen J;Chen G;Zhang J;Li Y;Xiong Y;Wang R;Cao Y;Chen Q;Liu D;Wang H;Chen J
中国在2013年初发现H7N9禽流感病毒后，对候鸟体内的禽流感病毒进行了主动监测，随后从候鸟的新鲜粪便中提取了两株H7N7毒株，这两株毒株来自不同的宿主和采样地点。系统发育和序列相似性网络分析表明，这两个H7N7病毒的几个基因与家禽中流行的禽流感病毒的基因关系密切，尽管两个分离株的基因片段不同。这强烈地表明，来自感染候鸟的病毒的基因已经被引入感染家禽的菌株。对所有八个片段的贝叶斯系统发育重建表明，这些病毒的进化过程中发生了多次重组，特别是在2011年底和2014年初。用血凝抑制试验进行的抗原性分析表明，这两种H7N7病毒与H7N9特异性抗血清有中度交叉反应。对两种H7N7病毒在不同的pH和温度条件下保持感染的能力进行了评估，其中在近中性和低温条件下病毒保持的时间最长。动物感染实验表明，该病毒对小鼠无毒力，不能从任何器官中恢复。我们的结果表明，低致病性、发散的H7N7病毒在东亚-澳大拉西亚飞行路线内传播。病毒在候鸟和家禽之间的传播可能会增加出现新的史无前例的毒株的风险。
After the emergence of H7N9 avian influenza viruses (AIV) in early 2013 in China, active surveillance of AIVs in migratory birds was undertaken, and two H7N7 strains were subsequently recovered from the fresh droppings of migratory birds; the strains were from different hosts and sampling sites. Phylogenetic and sequence similarity network analyses indicated that several genes of the two H7N7 viruses were closely related to those in AIVs circulating in domestic poultry, although different gene segments were implicated in the two isolates. This strongly suggested that genes from viruses infecting migratory birds have been introduced into poultry-infecting strains. A Bayesian phylogenetic reconstruction of all eight segments implied that multiple reassortments have occurred in the evolution of these viruses, particularly during late 2011 and early 2014. Antigenic analysis using a hemagglutination inhibition test showed that the two H7N7 viruses were moderately cross-reactive with H7N9-specific anti-serum. The ability of the two H7N7 viruses to remain infectious under various pH and temperature conditions was evaluated, and the viruses persisted the longest at near-neutral pH and in cold temperatures. Animal infection experiments showed that the viruses were avirulent to mice and could not be recovered from any organs. Our results indicate that low pathogenic, divergent H7N7 viruses circulate within the East Asian-Australasian flyway. Virus dispersal between migratory birds and domestic poultry may increase the risk of the emergence of novel unprecedented strains.
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影响因子：
13.2
作者：
Krauss S;Stucker KM;Schobel SA;Danner A;Friedman K;Knowles JP;Kayali G;Niles LJ;Dey AD;Raven G;Pryor P;Lin X;Das SR;Stockwell TB;Wentworth DE;Webster RG
通讯作者：
Webster RG
人类感染新型禽源甲型流感 (H7N9) 病毒。
影响因子：
158.5
作者：
Gao, Rongbao;Cao, Bin;Shu, Yuelong
通讯作者：
Shu, Yuelong
过去、现在和未来可能的人类感染甲型流感病毒 H7 亚型。
影响因子：
11.8
作者：
Belser, Jessica A.;Bridges, Carolyn B.;Katz, Jacqueline M.;Tumpey, Terrence M.
通讯作者：
Tumpey, Terrence M.
影响因子：
3.3
作者：
Kim, Min-Chul;Jeong, Ok-Mi;Lee, Youn-Jeong
通讯作者：
Lee, Youn-Jeong
影响因子：
2.7
作者：
Chen, Jianjun;Yan, Bin;Chen, Ze
通讯作者：
Chen, Ze