Resting-state functional connectivity of the amygdala and longitudinal changes in depression severity in adolescent depression.
Resting-state functional connectivity of the amygdala and longitudinal changes in depression severity in adolescent depression.
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DOI：
10.1016/j.jad.2016.09.026
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发表时间：
2017-01-01
影响因子：
6.6
通讯作者：
Yang TT
中科院分区：
文献类型：
--
作者：
Connolly CG;Ho TC;Blom EH;LeWinn KZ;Sacchet MD;Tymofiyeva O;Simmons AN;Yang TT
重度抑郁症（MDD）的发病率在青春期上升，但在这一关键发育时期的MDD的神经机制尚不清楚。杏仁核静息态功能连接（RSFC）改变与青少年和成人MDD以及成人治疗后症状改善相关。然而，迄今为止还没有研究探讨杏仁核RSFC是否与青少年抑郁症状严重程度的变化有关。我们在横断面上研究了药物初治抑郁青少年（N=48）和匹配良好的健康对照组（N=53）之间杏仁核RSFC的组间差异。然后，我们纵向研究了基线杏仁核RSFC是否与MDD组（N=24）的一个亚组三个月后抑郁症状的变化相关。与健康对照组相比，抑郁青少年表现出减少杏仁核为基础的RSFC与背外侧前额叶皮层（DLPFC）和腹内侧前额叶皮层（VMPFC）。在抑郁组中，杏仁核和岛叶之间更积极的基线RSFC与三个月后抑郁症状的减少有关。只有一部分抑郁症参与者在随访时进行了评估，治疗类型和治疗方法没有标准化。青少年抑郁症的特征可能是支持情绪调节的额边缘回路（杏仁核-DLPFC，杏仁核-VMPFC）功能障碍，而这些回路（杏仁核-杏仁核）辅助情感整合可能是抑郁症症状严重程度变化的指标，因此可能作为治疗反应的候选生物标志物。此外，这些结果表明，MDD存在的生物标志物与随着时间的推移与抑郁症状变化相关的生物标志物不同。
The incidence of major depressive disorder (MDD) rises during adolescence, yet the neural mechanisms of MDD during this key developmental period are unclear. Altered amygdala resting-state functional connectivity (RSFC) has been associated with both adolescent and adult MDD, as well as symptom improvement in response to treatment in adults. However, no study to date has examined whether amygdala RSFC is associated with changes in depressive symptom severity in adolescents. We examined group differences in amygdala RSFC between medication-naïve depressed adolescents (N=48) and well-matched healthy controls (N=53) cross-sectionally. We then longitudinally examined whether baseline amygdala RSFC was associated with change in depression symptoms three months later in a subset of the MDD group (N=24). Compared to healthy controls, depressed adolescents showed reduced amygdala-based RSFC with the dorsolateral prefrontal cortex (DLPFC) and the ventromedial prefrontal cortex (VMPFC). Within the depressed group, more positive baseline RSFC between the amygdala and insulae was associated with greater reduction in depression symptoms three months later. Only a subset of depressed participants was assessed at follow-up and treatment type and delivery were not standardized. Adolescent depression may be characterized by dysfunction of frontolimbic circuits (amygdala-DLPFC, amygdala-VMPFC) underpinning emotional regulation, whereas those circuits (amygdala-insula) subserving affective integration may index changes in depression symptom severity and may therefore potentially serve as a candidate biomarker for treatment response. Furthermore, these results suggest that the biomarkers of MDD presence are distinct from those associated with change in depression symptoms over time.
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影响因子：
10.6
作者：
Drevets, WC
通讯作者：
Drevets, WC
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
25.8
作者：
Cullen, Kathryn R.;Westlund, Melinda K.;Klimes-Dougan, Bonnie;Mueller, Bryon A.;Houri, Alaa;Eberly, Lynn E.;Lim, Kelvin O.
通讯作者：
Lim, Kelvin O.
DOI：
10.1098/rstb.1996.0125
发表时间：
1996-10-29
影响因子：
6.3
作者：
Damasio, AR
通讯作者：
Damasio, AR
影响因子：
5.3
作者：
Erk, Susanne;Mikschl, Alexandra;Walter, Henrik
通讯作者：
Walter, Henrik