The antidepressant-like effect of fisetin involves the serotonergic and noradrenergic system
The antidepressant-like effect of fisetin involves the serotonergic and noradrenergic system
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非瑟酮的抗抑郁样作用涉及血清素能和去甲肾上腺素能系统
DOI：
10.1016/j.bbr.2011.12.017
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发表时间：
2012-03
影响因子：
2.7
通讯作者：
ong
中科院分区：
文献类型：
--
作者：
Zhen, Linlin;Xu, Ying;Pan, Jianchun;Zhu, Jiejin;Zhao, Xin;Huang, Wu;An, Yiran;Li, Shan;Du, Xia;Lin, Mengmeng;Wang, Qi;ong
黄酮类化合物是一种多酚类化合物，具有显著的抗氧化和抗炎活性。非瑟酮（3，3 ′，4 ′，7-tetrahydroxyflavone，Fisetin）是一种重要的黄酮类化合物。本研究旨在探讨非瑟酮的抗抑郁作用及其可能机制。采用两种小鼠绝望模型评价非瑟酮的抗抑郁样作用。结果表明，非瑟酮10和20 mg/kg，p.o.在两种行为测试中，剂量依赖性地抑制不动时间，而影响不动反应的剂量不影响运动活性。两种行为模型，利血平诱导的体温过低和上睑下垂，和对氯苯丙氨酸（PCPA）诱导的5-羟色胺耗竭，探讨可能参与的非瑟酮在去甲肾上腺素能和肾上腺素能系统。高剂量的非瑟酮能有效地对抗利血平引起的体温降低，但对上睑下垂无明显作用。在强迫游泳和悬尾试验中，PCPA预处理可消除非瑟酮的抗不动作用。此外，神经化学分析表明，非瑟酮引起额叶皮层和海马体中5-羟色胺和去甲肾上腺素水平的增加。用非瑟酮处理后，小鼠脑中单胺氧化酶（MAO）活性被抑制了14.7%，而MAO-B活性不受影响。这些发现表明，非瑟酮的抗抑郁样作用涉及中枢5-羟色胺和去甲肾上腺素水平的调节。
Flavonoids, which are polyphenolic compounds, have been reported to possess remarkable antioxidant and anti-inflammatory activities. Among the dietary flavonoids, fisetin (3,3′,4′,7-tetrahydroxyflavone) possesses a significant spectrum of biochemical and pharmacological actions. The present study aimed to investigate the antidepressant potential of fisetin and its possible mechanism. Two mouse models of despair tests were used to evaluate the antidepressant-like effect of fisetin. The results suggested that fisetin (10 and 20mg/kg, p.o.) dose dependently inhibited the immobility time in both behavioral tests, while the doses that affected the immobile response did not affect locomotor activity. Two behavioral models, reserpine-induced hypothermia and ptosis, and p-chlorophenylalanine (PCPA)-induced depletion of serotonin, were used to explore the possible involvement of fisetin in the noradrenergic and serotonergic system. The higher dose of fisetin was found to effectively antagonize the hypothermia, but not ptosis, induced by reserpine. Pre-treatment with PCPA abolished the anti-immobility effect of fisetin in the forced swimming and tail suspension tests. Moreover, neurochemical assays showed that fisetin produced an increase in serotonin and noradrenaline levels in the frontal cortex and hippocampus. Monoamine oxidase (MAO) activity in the mouse brain was inhibited by 14.7% after treatment with fisetin, while MAO-B activity was not affected. These findings indicate that the antidepressant-like effect of fisetin involves the regulation of the central serotonin and noradrenaline levels.
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影响因子：
3.4
作者：
Kumar, Baldeep;Kuhad, Anurag;Chopra, Kanwaljit
通讯作者：
Chopra, Kanwaljit
DOI：
10.1016/j.pnpbp.2010.06.024
发表时间：
2010-10
影响因子：
5.6
作者：
Li-Tao Yi;Cheng-fu Li;X. Zhan;C. Cui;Fei Xiao;Li-Pan Zhou;Yong Xie
通讯作者：
Li-Tao Yi;Cheng-fu Li;X. Zhan;C. Cui;Fei Xiao;Li-Pan Zhou;Yong Xie
影响因子：
2.5
作者：
A. Nitta;Y. Furukawa;K. Hayashi;M. Hiramatsu;T. Kameyama;T. Hasegawa;T. Nabeshima
通讯作者：
A. Nitta;Y. Furukawa;K. Hayashi;M. Hiramatsu;T. Kameyama;T. Hasegawa;T. Nabeshima
影响因子：
3.3
作者：
J. Häggendal;A. Dahlström
通讯作者：
J. Häggendal;A. Dahlström
影响因子：
3.5
作者：
Maher, Pamela
通讯作者：
Maher, Pamela