Altered functional brain networks in Prader-Willi syndrome.
Altered functional brain networks in Prader-Willi syndrome.
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DOI：
10.1002/nbm.2900
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发表时间：
2013-06
影响因子：
2.9
通讯作者：
Liu, Yijun
中科院分区：
文献类型：
--
作者：
Zhang, Yi;Zhao, Heng;Qiu, Siyou;Tian, Jie;Wen, Xiaotong;Miller, Jennifer L.;von Deneen, Karen M.;Zhou, Zhenyu;Gold, Mark S.;Liu, Yijun
关键词：
Prader-Willi综合征（PWS）是一种遗传性印迹疾病，主要表现为摄食过多和儿童早期肥胖。以前的功能性神经影像学研究使用视觉刺激来检查PWS患者饮食相关神经回路的异常活动。结果发现，PWS患者表现出过度饥饿和暴食一致，即使在没有任何食物刺激的情况下。在本研究中，我们采用静息态功能磁共振成像技术来研究PWS儿童与进食障碍相关的异常脑网络。首先，我们应用低频波动幅度分析来定义感兴趣的区域，这些区域与他们的同胞对照组相比，在患者的静息态脑活动水平上显示出显着的变化。然后，我们对这些感兴趣的区域进行功能连接（FC）分析，以表征大脑区域之间的相互作用。结果表明，PWS患者在默认模式网络中表现为内侧前额叶皮层（MPFC）/顶下叶（IPL）、MPFC/楔前叶、IPL/楔前叶和IPL/海马的FC强度降低，在运动感觉网络和前额叶皮层网络中表现为中央前回/后回和背外侧前额叶皮层（DLPFC）/眶额皮层（OFC）的FC强度降低;在核心网络和前额叶网络中，前扣带皮层/前额叶皮层、腹外侧前额叶皮层/OFC和DLPFC/VLPFC的FC强度分别增加。这些研究结果表明，有FC之间的改变，涉及饮食以及奖励，即使在休息状态，这可能提供进一步的证据支持使用PWS作为模型来研究肥胖和提供信息的潜在神经靶点的药物治疗暴饮暴食。
Prader–Willi syndrome (PWS) is a genetic imprinting disorder characterized mainly by hyperphagia and early childhood obesity. Previous functional neuroimaging studies used visual stimuli to examine abnormal activities in the eating-related neural circuitry of patients with PWS. It was found that patients with PWS exhibited both excessive hunger and hyperphagia consistently, even in situations without any food stimulation. In the present study, we employed resting-state functional MRI techniques to investigate abnormal brain networks related to eating disorders in children with PWS. First, we applied amplitude of low-frequency fluctuation analysis to define the regions of interest that showed significant alterations in resting-state brain activity levels in patients compared with their sibling control group. We then applied a functional connectivity (FC) analysis to these regions of interest in order to characterize interactions among the brain regions. Our results demonstrated that patients with PWS showed decreased FC strength in the medial prefrontal cortex (MPFC)/inferior parietal lobe (IPL), MPFC/precuneus, IPL/precuneus and IPL/hippocampus in the default mode network; decreased FC strength in the pre-/postcentral gyri and dorsolateral prefrontal cortex (DLPFC)/orbitofrontal cortex (OFC) in the motor sensory network and prefrontal cortex network, respectively; and increased FC strength in the anterior cingulate cortex/insula, ventrolateral prefrontal cortex (VLPFC)/OFC and DLPFC/VLPFC in the core network and prefrontal cortex network, respectively. These findings indicate that there are FC alterations among the brain regions implicated in eating as well as rewarding, even during the resting state, which may provide further evidence supporting the use of PWS as a model to study obesity and to provide information on potential neural targets for the medical treatment of overeating.
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影响因子：
3.1
作者：
Dimitropoulos, A;Blackford, J;Thompson, T
通讯作者：
Thompson, T
影响因子：
4
作者：
Cassidy, SB
通讯作者：
Cassidy, SB
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM
DOI：
10.1111/j.1365-2788.2006.00812.x
发表时间：
2006-09-01
影响因子：
3.6
作者：
Hinton, E. C.;Holland, A. J.;Owen, A. M.
通讯作者：
Owen, A. M.
使用暴饮暴食模型研究食物成瘾。
影响因子：
5.4
作者：
Avena, Nicole M.
通讯作者：
Avena, Nicole M.