The study of food addiction using animal models of binge eating.

The study of food addiction using animal models of binge eating.
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使用暴饮暴食模型研究食物成瘾。

DOI:
10.1016/j.appet.2010.09.010
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发表时间:
2010-12
期刊:
影响因子:
5.4
通讯作者:
Avena, Nicole M.
Avena, Nicole M.
中科院分区:
医学2区
文献类型:
--
作者:
Avena, Nicole M.

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这篇综述总结了“食物成瘾”的证据,使用动物模型暴食。在我们的蔗糖暴食模型中,成瘾的行为成分被证明与成瘾药物也发生的神经化学变化有关。证据支持这一假设,即大鼠可以成为依赖和“上瘾”的蔗糖。当动物暴饮暴食其他可口的食物,包括富含脂肪的食物,所获得的结果进行了描述,并表明体重增加可能发生。然而,需要进一步探索在具有对脂肪的狂欢访问的动物中的成瘾样行为特征的表征,以将体重增加的影响与饮食或喂养时间表分离。
This review summarizes evidence of “food addiction” using animal models of binge eating. In our model of sucrose bingeing, behavioral components of addiction are demonstrated and related to neurochemical changes that also occur with addictive drugs. Evidence supports the hypothesis that rats can become dependent and “addicted” to sucrose. Results obtained when animals binge on other palatable foods, including a fat-rich food, are described and suggest that increased body weight can occur. However, the characterization of an addiction-like behavioral profile in animals with binge access to fat requires further exploration in order to dissociate the effect of increased body weight from the diet or schedule of feeding.
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