7T MRI-Histologic Correlation Study of Low Specific Absorption Rate T2-Weighted GRASE Sequences in the Detection of White Matter Involvement in Multiple Sclerosis.
7T MRI-Histologic Correlation Study of Low Specific Absorption Rate T2-Weighted GRASE Sequences in the Detection of White Matter Involvement in Multiple Sclerosis.
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DOI：
10.1111/jon.12238
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发表时间：
2015-05
期刊：
影响因子：
--
通讯作者：
Welch EB
中科院分区：
文献类型：
--
作者：
Bagnato F;Hametner S;Pennell D;Dortch R;Dula AN;Pawate S;Smith SA;Lassmann H;Gore JC;Welch EB
T2加权(T2-W)涡轮自旋回波(TSE)磁共振成像中射频重聚焦脉冲序列产生的射频能量的比吸收率(SAR)很高，这阻碍了其在7.0T(7T)下的临床应用。T2-w梯度和自旋回波(GRASE)利用梯度重聚焦的速度和自旋回波重聚焦的化学位移/静磁场(B0)不均匀性来获取具有有限数量重聚焦RF脉冲的T2-w图像，从而降低了SAR。目的探讨低SART2-wGRASE能否替代T2-wTSE在7T扫描MS患者脑白质(WM)病变中的应用。在7T扫描仪上从MS脑的尸检标本获得了具有可变回声时间(TES)和回波平面成像(EPI)因子的0.7mm~3各向同性T2-wTSE和T2-wGRASE图像。这些样本来自3名女性多发性硬化症患者的大脑。比较WM-LS与正常WM(NAWM)信号强度、WM-LS/NAWM对比噪声比(CNR)和MRI/髓鞘染色切片。EPI因子/TE=3/50和3/75ms的GRAS序列在测量WM-LS和NAWM的CNR和检测WM-LS方面与SE技术相当。然而，在所有序列中，不可能识别髓鞘染色所描绘的具有重新髓鞘形成、沃勒变性和灰质脱髓鞘的区域。T2-W Grase图像有可能取代T2-W TSE应用于临床。然而，即使在7T，这两个序列也无法检测和表征可见的WM-L以外的MS疾病。
The high value of the specific absorption rate (SAR) of radio-frequency (RF) energy arising from the series of RF refocusing pulses in T2-weighted (T2-w) turbo spin echo (TSE) MRI hampers its clinical application at 7.0 Tesla (7T). T2-w gradient and spin echo (GRASE) uses the speed from gradient refocusing in combination with the chemical-shift/static magnetic field (B0) inhomogeneity insensitivity from spin-echo refocusing to acquire T2-w images with a limited number of refocusing RF pulses, thus reducing SAR. To investigate whether low SAR T2-w GRASE could replace T2-w TSE in detecting white matter (WM) disease in MS patients imaged at 7T. The .7 mm3 isotropic T2-w TSE and T2-w GRASE images with variable echo times (TEs) and echo planar imaging (EPI) factors were obtained on a 7T scanner from postmortem samples of MS brains. These samples were derived from brains of 3 female MS patients. WM lesions (WM-Ls) and normal-appearing WM (NAWM) signal intensity, WM-Ls/NAWM contrast-to-noise ratio (CNR) and MRI/myelin staining sections comparisons were obtained. GRASE sequences with EPI factor/TE = 3/50 and 3/75 ms were comparable to the SE technique for measures of CNR in WM-Ls and NAWM and for detection of WM-Ls. In all sequences, however, identification of areas with remyelination, Wallerian degeneration, and gray matter demyelination, as depicted by myelin staining, was not possible. T2-w GRASE images may replace T2-w TSE for clinical use. However, even at 7T, both sequences fail in detecting and characterizing MS disease beyond visible WM-Ls.
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影响因子：
3.3
作者：
Fishbein, Kenneth W.;Gluzband, Yehezkiel A.;Spencer, Richard G.
通讯作者：
Spencer, Richard G.
DOI：
10.1111/j.1552-6569.2008.00338.x
发表时间：
2010-04
期刊：
Journal of neuroimaging : official journal of the American Society of Neuroimaging
影响因子：
--
作者：
Metcalf M;Xu D;Okuda DT;Carvajal L;Srinivasan R;Kelley DA;Mukherjee P;Nelson SJ;Vigneron DB;Pelletier D
通讯作者：
Pelletier D
影响因子：
4.4
作者：
Bagnato, Francesca;Yao, Bing;Cantor, Fredric;Merkle, Hellmut;Condon, Ellen;Montequin, Marcela;Moore, Sandra;Quezado, Martha;Tkaczyk, Deborah;McFarland, Henry
通讯作者：
McFarland, Henry
影响因子：
5.8
作者：
Mistry, Niraj;Tallantyre, Emma C.;Evangelou, Nikos
通讯作者：
Evangelou, Nikos
DOI：
10.1006/jmrb.1996.0042
发表时间：
1996-03-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
Kennan, RP;Richardson, KA;Gore, JC
通讯作者：
Gore, JC