TumorHoPe: a database of tumor homing peptides.
TumorHoPe: a database of tumor homing peptides.
复制标题
DOI：
10.1371/journal.pone.0035187
复制
发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Raghava GP
中科院分区：
文献类型：
--
作者：
Kapoor P;Singh H;Gautam A;Chaudhary K;Kumar R;Raghava GP
癌症每年造成数百万未成年人死亡，是发展中国家的经济负担。当今时代的主要挑战之一是设计能够特异性靶向肿瘤细胞而不是正常细胞的药物。在这种背景下，肿瘤归巢肽引起了人们的广泛关注。这些肽在肿瘤组织中以高特异性递送药物方面发挥着至关重要的作用。为了更好地为科学界服务，我们开发了一个肿瘤归巢肽数据库TumorHoPe。TumorHoPe是实验验证的肿瘤归巢肽的手动管理的数据库，其特异性识别肿瘤细胞和肿瘤相关微环境，即，血管生成这些肽是从已发表的论文、专利和数据库中收集和编辑的。目前发布的TumorHoPe包含744种肽。每个条目提供了肽的全面信息，包括其序列，靶肿瘤，靶细胞，鉴定技术，肽受体等。此外，我们还从这些肽序列中获得了各种类型的信息，包括二级/三级结构，氨基酸组成和肽的理化性质。已发现该数据库中的肽靶向不同类型的肿瘤，包括乳腺、肺、前列腺、黑色素瘤、结肠等。这些肽具有一些共同的基序，包括RGD（Arg-Gly-Asp）和NGR（Asn-Gly-Arg）基序，其特异性识别肿瘤血管生成标记物。TumorHoPe已与许多基于网络的工具集成，如简单/复杂搜索，数据库浏览和肽图谱。这些工具允许用户根据其氨基酸组成、电荷、极性、疏水性等搜索肿瘤归巢肽。TumorHoPe是同类中唯一的数据库，它提供了有关实验验证的肿瘤归巢肽及其靶细胞的全面信息。该数据库将为肽类药物和药物传递系统的设计提供参考。它可以在http://crdd.osdd.net/raghava/tumorhope/上免费获得。
Cancer is responsible for millions of immature deaths every year and is an economical burden on developing countries. One of the major challenges in the present era is to design drugs that can specifically target tumor cells not normal cells. In this context, tumor homing peptides have drawn much attention. These peptides are playing a vital role in delivering drugs in tumor tissues with high specificity. In order to provide service to scientific community, we have developed a database of tumor homing peptides called TumorHoPe. TumorHoPe is a manually curated database of experimentally validated tumor homing peptides that specifically recognize tumor cells and tumor associated microenvironment, i.e., angiogenesis. These peptides were collected and compiled from published papers, patents and databases. Current release of TumorHoPe contains 744 peptides. Each entry provides comprehensive information of a peptide that includes its sequence, target tumor, target cell, techniques of identification, peptide receptor, etc. In addition, we have derived various types of information from these peptide sequences that include secondary/tertiary structure, amino acid composition, and physicochemical properties of peptides. Peptides in this database have been found to target different types of tumors that include breast, lung, prostate, melanoma, colon, etc. These peptides have some common motifs including RGD (Arg-Gly-Asp) and NGR (Asn-Gly-Arg) motifs, which specifically recognize tumor angiogenic markers. TumorHoPe has been integrated with many web-based tools like simple/complex search, database browsing and peptide mapping. These tools allow a user to search tumor homing peptides based on their amino acid composition, charge, polarity, hydrophobicity, etc. TumorHoPe is a unique database of its kind, which provides comprehensive information about experimentally validated tumor homing peptides and their target cells. This database will be very useful in designing peptide-based drugs and drug-delivery system. It is freely available at http://crdd.osdd.net/raghava/tumorhope/.
登录
查看更多内容
影响因子：
5.7
作者：
Jiang, Yong-Qiang;Wang, Hai-Rong;Gu, Jun
通讯作者：
Gu, Jun
影响因子：
1.8
作者：
Lata S;Bhasin M;Raghava GP
通讯作者：
Raghava GP
DOI：
10.1083/jcb.200910104
发表时间：
2010-03-22
期刊：
The Journal of cell biology
影响因子：
--
作者：
Ruoslahti E;Bhatia SN;Sailor MJ
通讯作者：
Sailor MJ
MimoDB：源自噬菌体展示技术的模拟表位数据的新存储库
DOI：
10.3390/molecules15118279
发表时间：
2010-11-15
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Ru B;Huang J;Dai P;Li S;Xia Z;Ding H;Lin H;Guo F;Wang X
通讯作者：
Wang X
DOI：
10.1073/pnas.78.6.3824
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
HOPP, TP;WOODS, KR
通讯作者：
WOODS, KR