Angle Distribution Measurement of Scattered Light Intensity From Needle-Shaped Crystals in a Magnetic Field for Gout Diagnosis
Angle Distribution Measurement of Scattered Light Intensity From Needle-Shaped Crystals in a Magnetic Field for Gout Diagnosis
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磁场中针状晶体散射光强度的角度分布测量用于痛风诊断
DOI：
10.1109/tmag.2020.3006556
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发表时间：
2021
影响因子：
2.1
通讯作者：
Hamasaki Atom
中科院分区：
文献类型：
--
作者：
Takeuchi Yuka;Iwasaka Masakazu;Matsuda Mizushi;Hamasaki Atom
引起痛风的尿酸单钠（MSU）形成针状晶体，具有大的抗磁磁化率各向异性，在高达500 mT的磁场中取向。MSU悬浮液的光透射率和反射率在外加磁场下发生变化。为了利用这种现象来诊断痛风，有必要从各个角度收集光散射信息，包括透射和反射。这是因为在近红外（NIR）光（785 nm）下，来自MSU晶体的散射光强度在前向、侧向和后向方向上是不同的，近红外（NIR）光具有高生物渗透性并且用于NIR光谱学。因此，我们测量了MSU晶体在施加磁场之前和之后的光散射的角分布，并评估了它们的特性。在痛风患者中发现的大小的MSU晶体的情况下，与没有磁场的情况相比，在施加磁场的情况下，散射光强度在所有角度都降低。散射光强度的变化率在前向和后向方向上较大，而在侧向方向上相对较小。这归因于由磁取向引起的散射截面减小和伴随的衍射行为变化的综合效应。我们的研究结果表明，对于痛风诊断，入射光应该是水平的，如果透射测量是可能的，大约30°的检测角是合适的。如果透射测量不可行，最好避免90°左右的检测角度。
Monosodium urate (MSU), which causes gout, forms needle-shaped crystals with large diamagnetic susceptibility anisotropy that orient in a magnetic field of up to 500 mT. The light transmittance and reflectance of MSU suspensions change under an applied magnetic field. To use this phenomenon to diagnose gout, it would be necessary to collect light scattering information from all angles, including transmission and reflection. This is because the scattered light intensity from MSU crystals is different in forward, sideward, and backward directions under near-infrared (NIR) light (785 nm), which has high biopermeability and is used in NIR spectroscopy. Therefore, we measured the angular distributions of light scattering by MSU crystals before and after applying a magnetic field and evaluated their characteristics. In the case of MSU crystals of the size found in gout patients, the scattered light intensity decreased at all angles under an applied magnetic field compared with that without a magnetic field. The change ratio of the scattered light intensity was large in the forward and backward directions and relatively small in the sideward directions. This was ascribed to the combined effects of the decrease in the scattering cross section caused by the magnetic orientation and the accompanying change in diffraction behavior. Our findings indicated that for gout diagnosis, the incident light should be horizontal and that if transmission measurement is possible, a detection angle of about 30° is suitable. If transmission measurement is not practical, it is better to avoid a detection angle of around 90°.
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