Cell biological regulation of division fate in vertebrate neuroepithelial cells.

Cell biological regulation of division fate in vertebrate neuroepithelial cells.
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DOI:
10.1002/dvdy.22684
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发表时间:
2011-08
影响因子:
2.5
通讯作者:
Link, Brian A.
Link, Brian A.
中科院分区:
生物学3区
文献类型:
--
作者:
Willardsen, Minde I.;Link, Brian A.

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发育中的神经系统来自神经上皮祖细胞,神经上皮祖细胞分裂产生所有成熟的神经元类型。为了形成适当的细胞类型补充,祖细胞必须产生有丝分裂后细胞,同时也要补充祖细胞池。祖细胞分裂可分为三种类型:对称性增殖型(产生两个祖细胞)、非对称性神经源性(产生一个祖细胞和一个有丝分裂后细胞)和对称神经源性(产生两个有丝分裂后细胞)。这些细胞分裂模式的适当比例需要固有的极性,这是定义神经上皮祖细胞的特征之一。单个祖细胞经历的分裂类型可能会受到细胞特征或行为的影响,这些特征或行为在祖细胞群体中是不同的。在这里,我们回顾了三个关键的细胞参数,不对称遗传,细胞周期动力学,和动间核迁移,以及这些特征如何影响祖细胞命运的可能机制。
The developing nervous system derives from neuroepithelial progenitor cells that divide to generate all of the mature neuronal types. For the proper complement of cell types to form, the progenitors must produce postmitotic cells, yet also replenish the progenitor pool. Progenitor divisions can be classified into three general types: symmetric proliferative (producing two progenitors), asymmetric neurogenic (producing one progenitor and one postmitotic cell) and symmetric neurogenic (producing two postmitotic cells). The appropriate ratios for these modes of cell division require intrinsic polarity, which is one of the characteristics that define neuroepithelial progenitor cells. The type of division an individual progenitor undergoes can be influenced by cellular features, or behaviors, which are heterogeneous within the population of progenitors. Here we review three key cellular parameters, asymmetric inheritance, cell cycle kinetics, and interkinetic nuclear migration, and the possible mechanisms for how these features influence progenitor fates.
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